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Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field
Abstract
In gel electrophoresis, nucleic acids and protein-detergent complexes larger than a threshold size all migrate at the same rate. For DNA molecules, this effect can be overcome by the simple procedure of periodically inverting the electric field. Tuning the frequency of the field inversions from 10 to 0.01 hertz, makes it possible to resolve selectively DNA's in the size range 15 to >700 kilobase pairs.
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Longmire, J. L., Lewis, A. K., Brown, N. C., Buckingham, J. M., Clark, L. M., Jones, M. D., Meincke, L. J., Meyne, J., Ratliff, R. L., Ray, F. A., et al. (1988) · Genomics · doi:10.1016/0888-7543(88)90104-8 · Cited by 301
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Metadata
- Authors
- Carle, G. F., Frank, M., & Olson, M. V.
- Venue
- Science
- Published
- 1986-04-04
- Volume
- 232
- Issue
- 4746
- Pages
- 65-68
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970818972
- Cited by
- 904
- References
- 0
- FWCI
- 159.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field. https://app.cochat.ai/papers/10.1126/science.3952500
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- Carle, G. F., Frank, M., & Olson, M. V. (1986). Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field. Science. https://doi.org/10.1126/science.3952500
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
