Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Mullaart, Erik; Boerrigter, Michael E.T.I.; Ravid, Rivka; Swaab, Dick F.; Vijg, Jan

doi:10.1016/0197-4580(90)90542-8

Cited by 201Alzheimer's disease research and treatmentsDNA Repair MechanismsDementia and Cognitive Impairment Research

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

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Mullaart, Erik, Boerrigter, Michael E.T.I., Ravid, Rivka, Swaab, Dick F., Vijg, Jan·1990·Neurobiology of Aging

DOI 10.1016/0197-4580(90)90542-8

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Abstract

It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

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Increased levels of both SSBs and DSBs are documented in AD, HD, PD, and ALS, and their accumulation correlates with important milestones in disease progression.
“A plethora of studies document increased levels of both SSBs and DSBs in AD, HD, PD, and ALS (Mullaart et al, 1990; Adamec et al, 1999; McKinnon, 2013, 2017; Madabhushi et al, 2014; Alt & Schwer, 2018; Shanbhag et al, 2019; Thadathil et al, 2021), and their accumulation seem to correlate with important milestones in disease progression.”
From Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease (2022) · cites this paper as Mullaart et al, 1990
In AD, a two-fold increase in DNA damage has been found in the cortex compared to healthy controls.
“In AD, a two-fold increase in DNA damage has been found in the cortex compared to healthy controls [113].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [113]

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Authors: Mullaart, E., Boerrigter, M. E. T. I., Ravid, R., Swaab, D. F., & Vijg, J.
Affiliations: Netherlands Organisation for Applied Scientific Research (NL)
Corresponding author: Vijg, Jan
ORCID: Mullaart, Erik
Swaab, Dick F.
Vijg, Jan
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1990-05
Volume: 11
Issue: 3
Pages: 169-173
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/0197-4580(90)90542-8
OpenAlex: W2072092279
Cited by: 201
References: 34
Citations by year: 2026: 1 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 11 · 2021: 5 · 2020: 16 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 5
FWCI: 1.61
Type: journal article
Language: en
Open access: green
pure.knaw.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
TNO Repository (submittedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, DNA damage, DNA strand breaks, cerebral cortex, alkali-labile sites, DNA repair, neuronal DNA damage, neuropathology
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, DNA Damage, Female, Humans, Male, Middle Aged

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Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

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