The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Developmentally Controlled Expression of Immunoglobulin V H Genes
Abstract
Although antibody diversity arises mainly from apparently random combinatorial and somatic mutational mechanisms acting upon a limited number of germline antibody genes, the antibody repertoire develops in an ordered fashion during mammalian ontogeny. A series of early pre-B and B-lymphocyte cell lines were examined to determine whether an ordered rearrangement of gene families of the variable region of immunoglobulin heavy chains (VH) may be the basis for the programmed development of the antibody response. The results indicated that the VH repertoire of fetal B-lineage cells is largely restricted to the VH 7183 gene family and that subsequent recruitment of additional VH gene families occurs during neonatal development. These results have important implications in understanding the ontogeny of immune function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rigby, P. W. J., Dieckmann, M., Rhodes, C., & Berg, P. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90052-3 · Cited by 11,401
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Somatic generation of antibody diversity.
Matthyssens, G., Hozumi, N., & Tonegawa, S. (1976) · PubMed · Cited by 3,244
Kearney, J. F., Radbruch, A., Liesegang, B., & Rajewsky, K. (1979) · The Journal of Immunology · doi:10.4049/jimmunol.123.4.1548 · Cited by 1,852
Self-citationThe structure and evolution of the human β-globin gene family
Efstratiadis, A. (1980) · Cell · doi:10.1016/0092-8674(80)90429-8 · Cited by 1,375
Sakano, H., Maki, R., Kurosawa, Y., Roeder, W., & Tonegawa, S. (1980) · Nature · doi:10.1038/286676a0 · Cited by 792
Ordered rearrangement of immunoglobulin heavy chain variable region segments
Alt, F. W., Yancopoulos, G. D., Blackwell, T. K., Wood, C., Thomas, E., Boss, M., Coffman, R., Rosenberg, N., Tonegawa, S., & Baltimore, D. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01955.x · Cited by 733
Bothwell, A. L. M., Paskind, M., Reth, M., Imanishi-Kari, T., Rajewsky, K., & Baltimore, D. (1981) · Cell · doi:10.1016/0092-8674(81)90089-1 · Cited by 671
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines
Yancopoulos, G. D., Desiderio, S. V., Paskind, M., Kearney, J. F., Baltimore, D., & Alt, F. W. (1984) · Nature · doi:10.1038/311727a0 · Cited by 638
Self-citationAlt, F., Rosenberg, N., Lewis, S., Thomas, E., & Baltimore, D. (1981) · Cell · doi:10.1016/0092-8674(81)90421-9 · Cited by 484
Cited by
Fais, F., Ghiotto, F., Hashimoto, S., Sellars, B., Valetto, A., Allen, S. L., Schulman, P., Vinciguerra, V. P., Rai, K., Rassenti, L. Z., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3009 · Cited by 872
Development of the Primary Antibody Repertoire
Alt, F. W., Blackwell, T. K., & Yancopoulos, G. D. (1987) · Science · doi:10.1126/science.3317825 · Cited by 615
MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS
Jung, D., Giallourakis, C., Mostoslavsky, R., & Alt, F. W. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115830 · Cited by 578
Li, Y. S., Hayakawa, K., & Hardy, R. R. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.3.951 · Cited by 559
Early Restriction of the Human Antibody Repertoire
Schroeder, H. W., Hillson, J. L., & Perlmutter, R. M. (1987) · Science · doi:10.1126/science.3118465 · Cited by 537
Self-citation
Metadata
- Authors
- Perlmutter, R. M., Kearney, J. F., Chang, S. P., & Hood, L. E.
- Venue
- Science
- Published
- 1985-03-29
- Volume
- 227
- Issue
- 4694
- Pages
- 1597-1601
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054488343
- Cited by
- 347
- References
- 29
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Developmentally Controlled Expression of Immunoglobulin V H Genes. https://app.cochat.ai/papers/10.1126/science.3975629
- The paper
- Perlmutter, R. M., Kearney, J. F., Chang, S. P., & Hood, L. E. (1985). Developmentally Controlled Expression of Immunoglobulin V H Genes. Science. https://doi.org/10.1126/science.3975629
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
