Responsiveness and receptive field size of carp horizontal cells are reduced by prolonged darkness and dopamine
Abstract
In the fish retina the interplexiform cells contain dopamine and provide a centrifugal pathway from the inner plexiform layer to horizontal cells of the outer plexiform layer. Dopamine application reduced the responsiveness and receptive field size of cone horizontal cells, as did a prolonged period of complete darkness. Other results suggest that the interplexiform cells may release dopamine after a prolonged period in the dark. The interplexiform-horizontal cell system may modify the strength of the antagonistic surrounds of retinal neurons as a function of time in the dark.
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Dopamine deficiency has been linked to impaired perceptual and electrophysiological response to contrast signals including those presented in a center surround paradigm.
“For example, dopamine deficiency has been linked to impaired perceptual and electrophysiological response to contrast signals including those presented in a center surround paradigm (41,42).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [42]
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Visual perception and its impairment in schizophrenia
Butler, P. D., Silverstein, S. M., & Dakin, S. C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.023 · Cited by 472 · see citing works
- Authors
- Mangel, S. C., & Dowling, J. E.
- Affiliations
- Harvard University (US)
- Venue
- Science
- Published
- 1985-09-13
- Volume
- 229
- Issue
- 4718
- Pages
- 1107-1109
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008998885
- Cited by
- 202
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 2 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 6 · 2013: 2 · 2012: 1
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY-00824, EY05102)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- horizontal cells, interplexiform cells, dopamine, prolonged darkness, receptive field size, cone photoreceptors, fish retina, inner plexiform layer, outer plexiform layer
- MeSH terms
- Animals, Darkness, Dopamine, Electrophysiology, Evoked Potentials, Fishes, Light, Membrane Potentials, Retina, Time Factors
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