The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Alternative RNA Processing: Determining Neuronal Phenotype
Abstract
On the basis of an analysis of the human and rat calcitonin genes and of a related gene, alternative RNA processing represents a developmental strategy of the brain to dictate tissue-specific patterns of polypeptide synthesis. This regulation allows the calcitonin gene to generate two messenger RNA's, one encoding the precursor of a novel neuropeptide, referred to as CGRP, which predominates in the brain, and the second encoding the precursor to the hormone calcitonin which predominates in thyroid C cells. The distribution of CGRP in the central and peripheral nervous system and in endocrine and other organ systems suggests potential functions in nociception, ingestive behavior, cardiovascular homeostasis, and mineral metabolism.
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Citations
Cites
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302
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Cited by
Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
Russell, F. A., King, R., Smillie, S.-J., Kodji, X., & Brain, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00034.2013 · Cited by 1,258
Diverse molecular functions of Hu proteins
Hinman, M. N., & Lou, H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8252-6 · Cited by 587
CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Russo, A. F., & Hay, D. L. (2023) · Physiological Reviews · doi:10.1152/physrev.00059.2021 · Cited by 382
Effects of Meal Ingestion on Plasma Amylin Concentration in NIDDM and Nondiabetic Humans
Butler, P. C., Chou, J., Carter, W. B., Wang, Y.-N., Bu, B.-H., Chang, D., Chang, J.-K., & Rizza, R. A. (1990) · Diabetes · doi:10.2337/diab.39.6.752 · Cited by 330
Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.
Brown, A. L., Graham, D. E., Nissley, S. P., Hill, D. J., Strain, A. J., & Rechler, M. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69282-8 · Cited by 321
Metadata
- Authors
- Rosenfeld, M. G., Amara, S. G., & Evans, R. M.
- Venue
- Science
- Published
- 1984-09-21
- Volume
- 225
- Issue
- 4668
- Pages
- 1315-1320
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079140157
- Cited by
- 230
- References
- 1
- FWCI
- 11.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenfeld, M. G., Amara, S. G., & Evans, R. M. (1984). Alternative RNA Processing: Determining Neuronal Phenotype. Science. https://doi.org/10.1126/science.6089345
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
