The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Suramin Protection of T Cells in Vitro Against Infectivity and Cytopathic Effect of HTLV-III
Abstract
A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these cells. Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis, and it is known to inhibit the reverse transcriptase of a number of retroviruses. Suramin has now been found to block in vitro the infectivity and cytopathic effect of HTLV-III at doses that are clinically attainable in human beings.
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Cites
Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D., & Gallo, R. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7415 · Cited by 5,043
Self-citationYoshida, M., Miyoshi, I., & Hinuma, Y. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.2031 · Cited by 2,169
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus
TEMIN, H. M., & MIZUTANI, S. (1970) · Nature · doi:10.1038/2261211a0 · Cited by 2,128
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses
BALTIMORE, D. (1970) · Nature · doi:10.1038/2261209a0 · Cited by 2,068
Cited by
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.
De Clercq, E. (2009) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2008.10.010 · Cited by 627
Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells
Coffey, R. J., Leof, E. B., Shipley, G. D., & Moses, H. L. (1987) · Journal of Cellular Physiology · doi:10.1002/jcp.1041320120 · Cited by 379
NARA, P. L., HATCH, W. C., DUNLOP, N. M., ROBEY, W. G., ARTHUR, L. O., GONDA, M. A., & FISCHINGER, P. J. (1987) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1987.3.283 · Cited by 272
Lack of response to suramin in patients with AIDS and AIDS-related complex
Kaplan, L. D., Wolfe, P. R., Volberding, P. A., Feorino, P., Abrams, D. I., Levy, J. A., Wong, R., Kaufman, L., & Gottlieb, M. S. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90108-2 · Cited by 60
Use of suramin in treatment of prostatic carcinoma refractory to conventional hormonal manipulation
LaRocca, R. V., Cooper, M. R., Uhrich, M., Danesi, R., Walther, M. M., Linehan, W. M., & Myers, C. E. (1991) · Urologic Clinics of North America · doi:10.1016/s0094-0143(21)01399-9 · Cited by 57
Metadata
- Authors
- Mitsuya, H., Popovic, M., Yarchoan, R., Matsushita, S., Gallo, R. C., & Broder, S.
- Venue
- Science
- Published
- 1984-10-12
- Volume
- 226
- Issue
- 4671
- Pages
- 172-174
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080920468
- Cited by
- 397
- References
- 4
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Suramin Protection of T Cells in Vitro Against Infectivity and Cytopathic Effect of HTLV-III. https://app.cochat.ai/papers/10.1126/science.6091268
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- Mitsuya, H., Popovic, M., Yarchoan, R., Matsushita, S., Gallo, R. C., & Broder, S. (1984). Suramin Protection of T Cells in Vitro Against Infectivity and Cytopathic Effect of HTLV-III. Science. https://doi.org/10.1126/science.6091268
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
