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The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells
Abstract
The antineoplastic agent adriamycin was coupled to an insoluble agarose support. This material was actively cytotoxic to L1210 cells in culture under conditions in which no free adriamycin could enter the cell. It is concluded that an agent whose principal target was previously thought to be DNA can exert its cytotoxic action solely by interaction at the cell surface.
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Citations
Cited by
Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II
Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., & Liu, L. F. (1984) · Science · doi:10.1126/science.6093249 · Cited by 1,538
Tewey, K. M., Chen, G. L., Nelson, E. M., & Liu, L. F. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)47282-6 · Cited by 887
Plosker, G. L., & Faulds, D. (1993) · Drugs · doi:10.2165/00003495-199345050-00011 · Cited by 223
Emphysema and bronchial secretory cell metaplasia induced in hamsters by human neutrophil products.
(1984) · PubMed · doi:10.1164/arrd.1984.129.1.155 · Cited by 119
DNA damage by drugs and radiation: What is important and how is it measured?
Whitaker, S. J. (1992) · European Journal of Cancer · doi:10.1016/0959-8049(92)90432-2 · Cited by 43
Metadata
- Authors
- Triton, T. R., & Yee, G.
- Venue
- Science
- Published
- 1982-07-16
- Volume
- 217
- Issue
- 4556
- Pages
- 248-250
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035215935
- Cited by
- 571
- References
- 0
- FWCI
- 71.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells. https://app.cochat.ai/papers/10.1126/science.7089561
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- Triton, T. R., & Yee, G. (1982). The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells. Science. https://doi.org/10.1126/science.7089561
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
