The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dynorphin and Vasopressin: Common Localization in Magnocellular Neurons
Abstract
The opioid peptide dynorphin is widely distributed in neuronal tissue of rats. By immunocytochemical methods, it was shown previously that dynorphin-like immunoreactivity is present in the posterior pituitary and the cells of the hypothalamic neurosecretory magnocellular nuclei which also are responsible for the synthesis of oxytocin, vasopressin, and their neurophysins. By using an affinity-purified antiserum to the non-enkephalin part of the dynorphin molecule it has now been demonstrated that dynorphin and vasopressin occur in the same hypothalamic cells of rats, whereas dynorphin and oxytocin occur in separate cells. Homozygous Brattleboro rats (deficient in vasopressin) have magnocellular neurons that contain dynorphin separate from oxytocin. Thus dynorphin and vasopressin, although they occur in the same cells, appear to be under separate genetic control and presumably arise from different precursors.
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Citations
Cites
Dynorphin-(1-13), an extraordinarily potent opioid peptide.
Goldstein, A., Tachibana, S., Lowney, L. I., Hunkapiller, M., & Hood, L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6666 · Cited by 882
Vandesande, F., & Dierickx, K. (1975) · Cell and Tissue Research · doi:10.1007/bf00218970 · Cited by 496
Cited by
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study
Mansour, A., Fox, C. A., Burke, S., Meng, F., Thompson, R. C., Akil, H., & Watson, S. J. (1994) · Journal of Comparative Neurology · doi:10.1002/cne.903500307 · Cited by 870
Self-citationAnatomy of the CNS opioid systems
Khachaturian, H., Lewis, M. E., Schäfer, M. K.-H., & Watson, S. J. (1985) · Trends in Neurosciences · doi:10.1016/0166-2236(85)90048-7 · Cited by 428
Self-citationMorphology of vasopressin and oxytocin neurones and their central and vascular projections
Sofroniew, M. V. (1983) · Progress in Brain Research · doi:10.1016/s0079-6123(08)64378-2 · Cited by 370
Lightman, S. L., & Young, W. S. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016858 · Cited by 324
Metadata
- Authors
- Watson, S. J., Akil, H., Fischli, W., Goldstein, A., Zimmerman, E., Nilaver, G., & van Wimersma Griedanus, T. B.
- Venue
- Science
- Published
- 1982-04-02
- Volume
- 216
- Issue
- 4541
- Pages
- 85-87
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010579678
- Cited by
- 415
- References
- 2
- FWCI
- 17.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Watson, S. J., Akil, H., Fischli, W., Goldstein, A., Zimmerman, E., Nilaver, G., & van Wimersma Griedanus, T. B. (1982). Dynorphin and Vasopressin: Common Localization in Magnocellular Neurons. Science. https://doi.org/10.1126/science.6121376
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