The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
At Least Three Human Type α Interferons: Structure of α2
Abstract
The sequence of a human leukocyte-derived complementary DNA (cDNA), Hif-2h, which directs the formation in Escherichia coli of a polypeptide, IFN-α1, with interferon (IFN) activity has been described. A second IFN cDNA, Hif-SN206, which also elicits synthesis of a biologically active IFN, IFN-α2, is described in this article. Whereas IFN-α2 is twice as active on human as on bovine cells, IFN-α1 is 10 to 20 times more active on bovine than on human cells. As deduced from the cDNA's, the messenger RNA's for the two IFN's differ in length and in 20 percent of the nucleotides; the mature IFN polypeptides differ in 17 percent of the amino acids. Both IFN-α1 and IFN-α2 differ from the lymphoblastoid IFN described by others. Therefore, at least three different IFN-α genes are expressed in man; studies on genomic DNA reveal the presence of at least eight IFN-related genes.
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Cites
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Self-citationSynthesis in E. coli of a polypeptide with human leukocyte interferon activity
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Cited by
Interferons at age 50: past, current and future impact on biomedicine
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The structure of eight distinct cloned human leukocyte interferon cDNAs
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Nguyen, V. D., Hatahet, F., Salo, K. E., Enlund, E., Zhang, C., & Ruddock, L. W. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-1 · Cited by 260
Metadata
- Authors
- Streuli, M., Nagata, S., & Weissmann, C.
- Venue
- Science
- Published
- 1980-09-19
- Volume
- 209
- Issue
- 4463
- Pages
- 1343-1347
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043048841
- Cited by
- 274
- References
- 17
- FWCI
- 18.47
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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