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Automated Synthesis of Gene Fragments
Abstract
The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6½ hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.
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Citations
Cited by
Sinha, N. D., Biernat, J., McManus, J., & Köster, H. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.11.4539 · Cited by 849
Gene Synthesis Machines: DNA Chemistry and Its Uses
Caruthers, M. H. (1985) · Science · doi:10.1126/science.3863253 · Cited by 784
Advancing drug discovery via artificial intelligence
Chan, H. C. S., Shan, H., Dahoun, T., Vogel, H., & Yuan, S. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.06.004 · Cited by 654
Organic synthesis in a modular robotic system driven by a chemical programming language
Steiner, S., Wolf, J., Glatzel, S., Andreou, A., Granda, J. M., Keenan, G., Hinkley, T., Aragon-Camarasa, G., Kitson, P. J., Angelone, D., et al. (2019) · Science · doi:10.1126/science.aav2211 · Cited by 622
Artificial Intelligence and Machine Learning Technology Driven Modern Drug Discovery and Development
Sarkar, C., Das, B., Rawat, V. S., Wahlang, J. B., Nongpiur, A., Tiewsoh, I., Lyngdoh, N. M., Das, D., Bidarolli, M., & Sony, H. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032026 · Cited by 347
Metadata
- Authors
- Alvarado-Urbina, G., Sathe, G. M., Liu, W.-C., Gillen, M. F., Duck, P. D., Bender, R., & Ogilvie, K. K.
- Venue
- Science
- Published
- 1981-10-16
- Volume
- 214
- Issue
- 4518
- Pages
- 270-274
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004531868
- Cited by
- 176
- References
- 0
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Automated Synthesis of Gene Fragments. https://app.cochat.ai/papers/10.1126/science.6169150
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- Alvarado-Urbina, G., Sathe, G. M., Liu, W.-C., Gillen, M. F., Duck, P. D., Bender, R., & Ogilvie, K. K. (1981). Automated Synthesis of Gene Fragments. Science. https://doi.org/10.1126/science.6169150
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
