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Teratocarcinomas and Mammalian Embryogenesis
Abstract
In the last decade there has emerged an appreciation of the remarkable similarity between the cells that give rise to teratocarcinomas in mice and the cells that give rise to the developing mouse embryo. The resemblance is so close that in certain instances the tumor stem cells can join with their embryonic counterparts and develop into a completely normal mouse. The availability of stem cell lines isolated from mouse teratocarcinomas has made possible a number of new biochemical, immunological, and genetic approaches to the study of early mammalian development.
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Citations
Cited by
Andrews, P. W. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90316-6 · Cited by 806
Three-dimensional tissue culture models in cancer biology
Kim, J. B. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.05.002 · Cited by 613
Pera, M. F., Reubinoff, B., & Trounson, A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.1.5 · Cited by 554
Surface antigens of human embryonic stem cells: changes upon differentiation in culture*
Draper, J. S., Pigott, C., Thomson, J. A., & Andrews, P. W. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00030.x · Cited by 470
Moss, E. G., & Tang, L. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00126-x · Cited by 328
Metadata
- Authors
- Martin, G. R.
- Venue
- Science
- Published
- 1980-08-15
- Volume
- 209
- Issue
- 4458
- Pages
- 768-776
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003932465
- Cited by
- 738
- References
- 0
- FWCI
- 16.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Teratocarcinomas and Mammalian Embryogenesis. https://app.cochat.ai/papers/10.1126/science.6250214
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- Martin, G. R. (1980). Teratocarcinomas and Mammalian Embryogenesis. Science. https://doi.org/10.1126/science.6250214
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.