Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro
Abstract
The human embryonal carcinoma cell lines NT2 /D1 and NT2 /B9, clonally derived from Tera-2, differentiate extensively in vitro when exposed to retinoic acid. This differentiation is marked by the appearance of several morphologically distinct cell types and by changes in cell surface phenotype, particularly by the disappearance of stage-specific embryonic antigen-3 (SSEA-3), which is characteristically expressed by human EC cells. Among the differentiated cells are neurons, which form clusters interconnected by extended networks of axon bundles, and which express tetanus toxin receptors and neurofilament proteins. These observations constitute the first instance of extensive somatic differentiation of a clonal human EC cell line in vitro.
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Mouse P19 and human NTera-2 clone D1 (NT2/D1) are EC cells that differentiate into neurons upon RA-treatment.
“Mouse P19 and human NTera-2 clone D1 (NT2/D1) are EC cells that differentiate into neurons upon RA-treatment [39-41].”
From Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation (2004) · cites this paper as [41]
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- Authors
- Andrews, P. W.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1984-06
- Volume
- 103
- Issue
- 2
- Pages
- 285-293
- ISSN
- 0012-1606
- Cited by
- 670
- References
- 0
- Language
- en
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