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Integration and Stable Germ Line Transmission of Genes Injected into Mouse Pronuclei
Abstract
Genetic material has been successfully transferred into the genomes of newborn mice by injection of that material into pronuclei of fertilized eggs. Initial results indicated two patterns of processing the injected DNA: one in which the material was not integrated into the host genome, and another in which the injected genes became associated with high molecular weight DNA. These patterns are maintained through further development to adulthood. The evidence presented indicates the covalent association of injected DNA with host sequences, and transmission of such linked sequences in a Mendelian distribution to two succeeding generations of progeny.
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Cited by
Ripps, M. E., Huntley, G. W., Hof, P. R., Morrison, J. H., & Gordon, J. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.689 · Cited by 722
Self-citationProspects for Human Gene Therapy
Anderson, W. F. (1984) · Science · doi:10.1126/science.6093246 · Cited by 533
Olsson, J. E., Gordon, J. W., Pawlyk, B. S., Roof, D., Hayes, A., Molday, R. S., Mukai, S., Cowley, G. S., Berson, E. L., & Dryja, T. P. (1992) · Neuron · doi:10.1016/0896-6273(92)90236-7 · Cited by 455
Self-citationAnimal Experiments in Biomedical Research: A Historical Perspective
Franco, N. (2013) · Animals · doi:10.3390/ani3010238 · Cited by 265
“In 1980 John Gordon and Franck Ruddle developed the first transgenic mouse [156], and in 1988, the first gene knockout model was produced, which granted”
BackgroundSite-specific integrase-mediated transgenesis in mice via pronuclear injection
Tasic, B., Hippenmeyer, S., Wang, C., Gamboa, M., Zong, H., Chen-Tsai, Y., & Luo, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019507108 · Cited by 246
Metadata
- Authors
- Gordon, J. W., & Ruddle, F. H.
- Venue
- Science
- Published
- 1981-12-11
- Volume
- 214
- Issue
- 4526
- Pages
- 1244-1246
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037755687
- Cited by
- 679
- References
- 0
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gordon, J. W., & Ruddle, F. H. (1981). Integration and Stable Germ Line Transmission of Genes Injected into Mouse Pronuclei. Science. https://doi.org/10.1126/science.6272397
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
