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Genetic Transformation of Drosophila with Transposable Element Vectors
Abstract
Exogenous DNA sequences were introduced into the Drosophila germ line. A rosy transposon (ry1), constructed by inserting a chromosomal DNA fragment containing the wild-type rosy gene into a P transposable element, transformed germ line cells in 20 to 50 percent of the injected rosy mutant embryos. Transformants contained one or two copies of chromosomally integrated, intact ry1 that were stably inherited in subsequent generations. These transformed flies had wild-type eye color indicating that the visible genetic defect in the host strain could be fully and permanently corrected by the transferred gene. To demonstrate the generality of this approach, a DNA segment that does not confer a recognizable phenotype on recipients was also transferred into germ line chromosomes.
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Cited by
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Halder, G., Callaerts, P., & Gehring, W. J. (1995) · Science · doi:10.1126/science.7892602 · Cited by 1,573
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
Ding, S., Wu, X., Li, G., Han, M., Zhuang, Y., & Xu, T. (2005) · Cell · doi:10.1016/j.cell.2005.07.013 · Cited by 1,009
The FLP recombinase of yeast catalyzes site-specific recombination in the drosophila genome
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Metadata
- Authors
- Rubin, G. M., & Spradling, A. C.
- Venue
- Science
- Published
- 1982-10-22
- Volume
- 218
- Issue
- 4570
- Pages
- 348-353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994528729
- Cited by
- 3,014
- References
- 0
- FWCI
- 47.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rubin, G. M., & Spradling, A. C. (1982). Genetic Transformation of Drosophila with Transposable Element Vectors. Science. https://doi.org/10.1126/science.6289436
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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