Cited by 959Neurobiology and Insect Physiology ResearchMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

Yin, J.C.P., Wallach, J.S., Del Vecchio, M., Wilder, E.L., Zhou, H., Quinn, W.G., Tully, T.·1994·Cell

Abstract

Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.

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Crossref · 10.1016/0092-8674(94)90399-9

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Previous efforts to find neurobiological explanations for the advantages of distributed practice obtained evidence that spaced trials can offset memory defects in mice lacking two variants of the transcription factor CREB.

    “Previous efforts to find neurobiological explanations for the advantages of distributed practice obtained evidence that spaced trials can offset memory defects in mice lacking two variants of the transcription factor CREB (31, 32).”

    From Synaptic evidence for the efficacy of spaced learning (2012) · cites this paper as [32]

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Authors
Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T.
Affiliations
  • Cold Spring Harbor Laboratory (US)
  • Massachusetts Institute of Technology (US)
  • Howard Hughes Medical Institute (US)
Venue
Cell
Publisher
Elsevier BV
Published
1994-10
Volume
79
Issue
1
Pages
49-58
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2076782084
Cited by
959
References
48
Citations by year
2026: 6 · 2025: 11 · 2024: 10 · 2023: 21 · 2022: 16 · 2021: 19 · 2020: 14 · 2019: 25 · 2018: 19 · 2017: 32 · 2016: 27 · 2015: 28 · 2014: 25 · 2013: 41 · 2012: 41
FWCI
13.95
Type
journal article
Language
en
Open access
closed
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders
  • National Institutes of Health (HD32245, NS25621)
  • National Cancer Institute
  • Cold Spring Harbor Laboratory
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
long-term memory, olfactory learning, dominant-negative CREB, de novo gene expression, memory consolidation, cycloheximide sensitivity, Drosophila
MeSH terms
Amino Acid Sequence, Animals, Conditioning, Classical, Drosophila, Genes, Dominant, Hot Temperature, Memory, Molecular Sequence Data, RNA, Messenger, Gene Expression, Genes, Insect, Cyclic AMP Response Element-Binding Protein, Animals, Genetically Modified

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