The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Multiple Point Mutations Affecting the Simian Virus 40 Enhancer
Abstract
Enhancers, or activators, dramatically increase the transcriptional activity of certain eukaryotic genes. A series of multiple point mutations affecting the simian virus 40 (SV40) enhancer-activator region were generated in order to define the nucleotide sequence required for this function. Three independent assays provided information leading to the identification of nucleotides essential for enhancer function. One class leads to a decrease in gene expression, while the second completely abolishes functional activity. One critical replacement appears to be the first G (guanine) in a sequence TGGAAAG (T, thymine, A, adenine) located in the 5' region of the 72 base-pair repeat of SV40. Comparison of this sequence with nucleotide sequences in other known enhancers leads to the identification of potential related core elements.
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Citations
Cites
Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
Banerji, J., Rusconi, S., & Schaffner, W. (1981) · Cell · doi:10.1016/0092-8674(81)90413-x · Cited by 1,724
In vivo sequence requirements of the SV40 early promoter region
Benoist, C., & Chambon, P. (1981) · Nature · doi:10.1038/290304a0 · Cited by 1,074
Cited by
Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80986-1 · Cited by 1,856
Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma
Herbomel, P., Bourachot, B., & Yaniv, M. (1984) · Cell · doi:10.1016/0092-8674(84)90472-0 · Cited by 837
Johnson, P. F., Landschulz, W. H., Graves, B. J., & McKnight, S. L. (1987) · Genes & Development · doi:10.1101/gad.1.2.133 · Cited by 595
Nordheim, A., & Rich, A. (1983) · Nature · doi:10.1038/303674a0 · Cited by 441
The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation
Meyers, S., Lenny, N., & Hiebert, S. W. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1974 · Cited by 368
Metadata
- Authors
- Weiher, H., König, M., & Gruss, P.
- Venue
- Science
- Published
- 1983-02-11
- Volume
- 219
- Issue
- 4585
- Pages
- 626-631
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968244375
- Cited by
- 832
- References
- 2
- FWCI
- 48.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
