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Pargyline Prevents MPTP-Induced Parkinsonism in Primates
Abstract
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin which produces permanent parkinsonism in human and nonhuman primates. Treatment of squirrel monkeys with pargyline, a monoamine oxidase (MAO) inhibitor, prevents both clinical and neuropathological evidence of the neurotoxic effects of MPTP. Pargyline also inhibits conversion of MPTP to 1-methyl-4-phenylpyridinium ion (MPP + ), a metabolic step that occurs rapidly after administration of MPTP in animals not treated with pargyline. It is proposed that the conversion of MPTP to MPP+, possibly involving MAO, may be important for the neurotoxic effects of MPTP to take place, and MPTP itself may not be the neurotoxic agent.
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Citations
Cited by
A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter
Liu, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90425-c · Cited by 594
Glutamate and Parkinson’s disease
Blandini, F., Porter, R. H. P., & Greenamyre, J. T. (1996) · Molecular Neurobiology · doi:10.1007/bf02740748 · Cited by 323
Monoamine oxidase and cigarette smoking
Fowler, J. S., Logan, J., Wang, G.-J., & Volkow, N. D. (2003) · NeuroToxicology · doi:10.1016/s0161-813x(02)00109-2 · Cited by 251
Martinovits, G., Melamed, E., Cohen, O., Rosenthal, J., & Uzzan, A. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90602-6 · Cited by 67
Iron-mediated bioactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in glial cultures
Di Monte, D. A., Schipper, H. M., Hetts, S., & Langston, J. W. (1995) · Glia · doi:10.1002/glia.440150213 · Cited by 43
Metadata
- Authors
- Langston, J. W., Irwin, I., Langston, E. B., & Forno, L. S.
- Venue
- Science
- Published
- 1984-09-28
- Volume
- 225
- Issue
- 4669
- Pages
- 1480-1482
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070849668
- Cited by
- 581
- References
- 0
- FWCI
- 59.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pargyline Prevents MPTP-Induced Parkinsonism in Primates. https://app.cochat.ai/papers/10.1126/science.6332378
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- Langston, J. W., Irwin, I., Langston, E. B., & Forno, L. S. (1984). Pargyline Prevents MPTP-Induced Parkinsonism in Primates. Science. https://doi.org/10.1126/science.6332378
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