The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Glycosylation of Hemoglobin: Relevance to Diabetes Mellitus
Abstract
Glucose reacts nonenzymatically with the NH 2 -terminal amino acid of the β chain of human hemoglobin by way of a ketoamine linkage, resulting in the formation of hemoglobin A Ic . Other minor components appear to be adducts of glucose 6-phosphate and fructose 1,6-diphosphate. These hemoglobins are formed slowly and continuously throughout the 120-day life-span of the red cell. There is a two- to threefold increase in hemoglobin A Ic in the red cells of patients with diabetes mellitus. By providing an integrated measurement of blood glucose, hemoglobin A Ic is useful in assessing the degree of diabetic control. Furthermore, this hemoglobin is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.
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Citations
Cites
A high‐performance liquid chromatography method for hemoglobin A1c
Davis, J. E., Mcdonald, J. M., & Jarett, L. (1978) · Diabetes · doi:10.2337/diab.27.2.102 · Cited by 203
Cole, R. A., Soeldner, J. S., Dunn, P. J., & Bunn, H. F. (1978) · Metabolism · doi:10.1016/0026-0495(78)90109-9 · Cited by 183
Self-citation
Cited by
Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569
Riess, J. G. (2001) · Chemical Reviews · doi:10.1021/cr970143c · Cited by 773
Reaction of Monosaccharides with Proteins: Possible Evolutionary Significance
Bunn, H. F., & Higgins, P. J. (1981) · Science · doi:10.1126/science.12192669 · Cited by 598
Self-citationDoes accumulation of advanced glycation end products contribute to the aging phenotype?
Semba, R. D., Nicklett, E. J., & Ferrucci, L. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq074 · Cited by 490
Lee, T. S., Saltsman, K. A., Ohashi, H., & King, G. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5141 · Cited by 373
Retracted
Metadata
- Authors
- Bunn, H. F., Gabbay, K. H., & Gallop, P. M.
- Venue
- Science
- Published
- 1978-04-07
- Volume
- 200
- Issue
- 4337
- Pages
- 21-27
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073620575
- Cited by
- 876
- References
- 2
- FWCI
- 48.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bunn, H. F., Gabbay, K. H., & Gallop, P. M. (1978). The Glycosylation of Hemoglobin: Relevance to Diabetes Mellitus. Science. https://doi.org/10.1126/science.635569
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
