A high‐performance liquid chromatography method for hemoglobin A1c
Abstract
Hemoglobin A1c (HbA1c) is a glycosylated derivative of hemoglobin and is one of a family of derivatives whose concentrations are elevated in patients with diabetes mellitus. Published methods for the measurement of HbA1c are relatively tedious and require modest amounts of blood. A high-performance liquid chromatographic (HPLC) method for the determination of HbA1c is presented. The method is rapid (20 minutes), precise (coefficient of variation of 5-10 per cent), uses small amounts of sample (3 microliter.), can be automated. A sample preparation technique using filtration was developed that shortened and simplified preparation of venous blood and allowed use of capillary samples. HbA1c was measured by this method in three age-stratified groups of controls and a group of insulin-requiring juvenile diabetics. There was clear separation of HbA1c values between all normals (5.9 +/- 1.3, 5.6 +/- 0.7, 7.1 +/- 0.9 per cent) and the diabetics (12.1 +/- 2.4 per cent). Use of this method can facilitate large-scale clinical investigations and permit biochemical investigations of the metabolism and formation of hemoglobin A1c where small sample sizes are necessary.
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Assays for glucose, insulin, C-peptide, FFA, and HbA1c had coefficients of variation below specified thresholds.
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From Twenty‐four‐hour profiles of plasma glucose, insulin, C‐peptide and free fatty acid in subjects with varying degrees of glucose tolerance following short‐term, medium‐dose prednisone (20 mg/day) treatment: evidence for differing effects on insulin secretion and action (2012) · cites this paper as [19]
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“, Torrance, CA, USA), photodiode-array detector Jasco MD-915 (Tokyo, Japan) and an Agilent UV- detector model 1100, was used to analyze folate and HbA1c concentrations [19,20].”
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A semi-automated method for the determination of glycosylated haemoglobin
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Recent Advances in Glycosylated Hemoglobin Measurements
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“HbA1c was measured with the HLPC (high-performance liquid chromatography) method [25], creatinine was measured with Jaffe’s colorimetric assay [26] (Cobas Integra 800, Roche Diagnostics®), and eGFR was calculated according to CKDEPI formula [27].”
MethodEffects of dietary cholesterol on plasma lipoproteins and their subclasses in IDDM patients
Romanò, G., Tilly-Kiesi, M., Patti, L., Taskinen, M., Pacioni, D., Cassader, M., Riccardi, G., & Rivellese, A. A. (1998) · Diabetologia · doi:10.1007/s001250050889 · Cited by 22 · see citing works
“HbA 1c was measured by a high pressure liquid chromatography [ 27 ].”
MethodPlasma Lipids in Patients With Type I Diabetes Mellitus
Semenkovich, C. F. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390010069006 · Cited by 22 · see citing works
Sun, L., Zhang, X., Wang, T., et al. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4866 · Cited by 20 · see citing works
“HbA1c levels were measured using high-performance liquid chromatography as previous described (20).”
MethodKordonouri, O., Jörres, A., Muller, C. R., et al. (1992) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519209088381 · Cited by 21 · see citing works
Comparison of hemoglobin A1c and hemoglobin A1 in diabetic patients
James, T., Davis, J. E., McDonald, J. M., Santiago, J. V., & Ladenson, J. H. (1981) · Clinical Biochemistry · doi:10.1016/0009-9120(81)90135-1 · Cited by 20 · see citing works
Self-citation
- Authors
- Davis, J. E., Mcdonald, J. M., & Jarett, L.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1978-02-01
- Volume
- 27
- Issue
- 2
- Pages
- 102-107
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2013055957
- Cited by
- 203
- References
- 0
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
- Keywords
- HbA1c, HPLC assay, diabetes mellitus, type 1 diabetes, capillary blood samples, sample preparation, small sample volumes, automated assay
- MeSH terms
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Chromatography, High Pressure Liquid, Diabetes Mellitus, Diabetes Mellitus, Type 1, Glycosides, Hemoglobins, Humans, Middle Aged
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