The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Homologies Between Signal Transducing G Proteins and ras Gene Products
Abstract
The guanosine triphosphate-binding proteins (G proteins) found in a variety of tissues transduce signals generated by ligand binding to cell surface receptors into changes in intracellular metabolism. Amino acid sequences of peptides prepared by partial proteolysis of the α subunit of a bovine brain G protein and the α subunit of rod outer-segment transducin were determined. The two proteins show regions of sequence identity as well as regions of diversity. A portion of the amino-terminal peptide sequence of each protein is highly homologous with the corresponding region in the ras protein (a protooncogene product). These similarities suggest that G proteins and ras proteins may have analogous functions.
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Cites
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
Cited by
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
RAS oncogenes: the first 30 years
Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902
Ras oncogenes: split personalities
Karnoub, A. E., & Weinberg, R. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2438 · Cited by 1,467
Ras history: The saga continues
Cox, A. D., & Der, C. J. (2010) · Small GTPases · doi:10.4161/sgtp.1.1.12178 · Cited by 706
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product
Calés, C., Hancock, J. F., Marshall, C. J., & Hall, A. (1988) · Nature · doi:10.1038/332548a0 · Cited by 386
Metadata
- Authors
- Hurley, J. B., Simon, M. I., Teplow, D. B., Robishaw, J. D., & Gilman, A. G.
- Venue
- Science
- Published
- 1984-11-16
- Volume
- 226
- Issue
- 4676
- Pages
- 860-862
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077102469
- Cited by
- 482
- References
- 1
- FWCI
- 28.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hurley, J. B., Simon, M. I., Teplow, D. B., Robishaw, J. D., & Gilman, A. G. (1984). Homologies Between Signal Transducing G Proteins and ras Gene Products. Science. https://doi.org/10.1126/science.6436980
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
