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Fidelity of Mammalian DNA Polymerases
Abstract
The fidelity of copying natural DNA in vitro with each of the three classes of eukaryotic DNA polymerases has been determined. DNA polymerases-β and -γ are highly inaccurate, catalyzing noncomplementary single-base substitution at a frequency between 1/3000 and 1/8000. DNA polymerase-α is substantially more accurate, with an error rate of 1/30,000. When the error rates of these DNA polymerases are considered in the context of the accuracy of DNA replicative processes in vivo, it seems likely that other factors must exist in mammalian cells which are involved in the accurate replication and maintenance of the genetic information.
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Cited by
Birky, C. W., Maruyama, T., & Fuerst, P. (1983) · Genetics · doi:10.1093/genetics/103.3.513 · Cited by 719
Loeb, L. A., & Kunkel, T. A. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.002241 · Cited by 511
Self-citationLack of evidence for proofreading mechanisms associated with an RNA virus polymerase
Steinhauer, D. A., Domingo, E., & Holland, J. J. (1992) · Gene · doi:10.1016/0378-1119(92)90216-c · Cited by 415
Kunkel, T. A., & Alexander, P. S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42446-x · Cited by 299
Self-citationMáximo, V., Soares, P., Lima, J., Cameselle-Teijeiro, J., & Sobrinho-Simões, M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61132-7 · Cited by 271
Metadata
- Authors
- Kunkel, T. A., & Loeb, L. A.
- Venue
- Science
- Published
- 1981-08-14
- Volume
- 213
- Issue
- 4509
- Pages
- 765-767
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050455558
- Cited by
- 178
- References
- 0
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
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