Fidelity of DNA Synthesis
Abstract
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
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In aqueous solution, free energy differences between complementary and non-complementary base pairs are 0.2-4 kcal/mol, which can account for one incorrect insertion for about 10 to a few hundred correct insertions.
“In aqueous solution, these differences are 0.2-4 kcal/mol, which can account for one incorrect insertion for about 10 to a few hundred correct insertions.”
From DNA Replication Fidelity (2004) · cites this paper as [25]
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- Authors
- Loeb, L. A., & Kunkel, T. A.
- ORCID
- Kunkel, T A
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1982-06
- Volume
- 51
- Issue
- 1
- Pages
- 429-457
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2174994538
- Cited by
- 511
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- DNA synthesis fidelity, DNA polymerase, DNA replication, mutagenesis, genome stability
- MeSH terms
- Animals, Cobalt, DNA, DNA-Directed DNA Polymerase, Humans, Isoenzymes, Kinetics, Magnesium, Manganese, Models, Chemical, Nickel, Nucleotides, Bacteriophage phi X 174, Polynucleotides, Templates, Genetic, Zinc
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