A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells.
Abstract
Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to a form that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor.
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The primary site of action of DHT on [3H]E2-specific binding was clearly consistent with a specific interaction with the AR, rather than a direct activation and processing of the ER by DHT.
“Thus, the primary site of action of DHT on [ 3 H]E 2 -specific binding was clearly consistent with a specific interaction with the AR, rather than a direct activation and processing of the ER by DHT (234 -239).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [238]
Cites
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Down-regulation of estrogen receptors by androgens in the ZR-75-1 human breast cancer cell line.
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- Authors
- Kasid, A., Strobl, J. S., Huff, K., Greene, G. L., & Lippman, M. E.
- Affiliations
- National Cancer Institute (US)
- University of Chicago (US)
- Venue
- Science
- Published
- 1984-09-14
- Volume
- 225
- Issue
- 4667
- Pages
- 1162-1165
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977186841
- Cited by
- 32
- References
- 18
- Citations by year
- 2025: 1
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Keywords
- nuclear estrogen receptor, estradiol receptor, MCF-7 cells, breast cancer, receptor modification, hormone responsiveness, receptor loss, ligand exchange
- MeSH terms
- Breast Neoplasms, Cell Nucleus, Cells, Cultured, Female, Humans, Receptors, Estradiol, Receptors, Estrogen, Receptors, Progesterone, Time Factors
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