Antiestrogenic properties of keoxifene trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells.

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922 · see citing works

Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications

Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146 · see citing works

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

Berthois, Y., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2496 · Cited by 1,307 · see citing works

Breast Tumor Cell Lines From Pleural Effusions2

Cailleau, R., Young, R. K., Olivé, M., & Reeves, W. J. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.3.661 · Cited by 1,019 · see citing works

The pharmacology and clinical uses of tamoxifen

Furr, B. J. A., & Jordan, V. C. (1984) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(84)90043-3 · Cited by 864 · see citing works

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

Dickson, R. B., & Lippman, M. E. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-1-29 · Cited by 566 · see citing works

A MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTIOESTROGENIC ACTIVITY

Jordan, V. C., Collins, M. M., Rowsby, L., et al. (1977) · Journal of Endocrinology · doi:10.1677/joe.0.0750305 · Cited by 506 · see citing works

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse.

Gottardis, M. M., Robinson, S. P., SATYASWAROOP, P. G., & Jordan, V. C. (1988) · PubMed · Cited by 422 · see citing works

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.

Katzenellenbogen, B. S., Kendra, K. L., Norman, M. J., et al. (1987) · PubMed · Cited by 410 · see citing works

Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.

Engel, L. W., Young, N. A., Tralka, T. S., Lippman, M. E., O’Brien, S. J., & Joyce, M. J. (1978) · PubMed · Cited by 371 · see citing works

Nuclear mechanisms of estrogen action. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing.

Horwitz, K. B., & McGuire, W. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34379-x · Cited by 346 · see citing works

STEROIDAL PURE ANTIOESTROGENS

Wakeling, A. E., & Bowler, J. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.112r007 · Cited by 323 · see citing works

Steroid receptor analyses of nine human breast cancer cell lines.

Horwitz, K. B., Zava, D. T., Thilagar, A. K., Jensen, E. M., & McGuire, W. L. (1978) · PubMed · Cited by 300 · see citing works

Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells.

Katzenellenbogen, B. S., Norman, M. J., Eckert, R. L., Peltz, S. W., & Mangel, W. F. (1984) · PubMed · Cited by 276 · see citing works

Antagonism of estrogen action with a new benzothiophene derived antiestrogen

Black, L. J., Jones, C. D., & Falcone, J. F. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90935-9 · Cited by 242 · see citing works

Use of the aromatase inhibitor 4-hydroxyandrostenedione in postmenopausal breast cancer: optimization of therapeutic dose and route.

Dowsett, M., Goss, P. E., Powles, T., Hutchinson, G., Brodie, A. M., Jeffcoate, S. L., & Coombes, R. C. (1987) · PubMed · Cited by 238 · see citing works

Novel antioestrogens without partial agonist activity

Wakeling, A. E., & Bowler, J. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90014-3 · Cited by 215 · see citing works

Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells.

Eckert, R. L., & Katzenellenbogen, B. S. (1982) · PubMed · Cited by 208 · see citing works

Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens

Vignon, F., Bouton, M. M., & Rochefort, H. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90819-9 · Cited by 203 · see citing works

Stimulation of cell proliferation and estrogenic response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line.

Poulin, R., & Labrie, F. (1986) · PubMed · Cited by 200 · see citing works

Estradiol-binding kinetics of the activated and nonactivated estrogen receptor.

Weichman, B. M., & Notides, A. C. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38319-9 · Cited by 190 · see citing works

Steroid receptor-mediated cytotoxicity of an antiestrogen and an antiprogestin in breast cancer cells.

Bardon, S., Vignon, F., Montcourrier, P., et al. (1987) · PubMed · Cited by 173 · see citing works

Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line.

Poulin, R., Baker, D., & Labrie, F. (1988) · Breast Cancer Research and Treatment · doi:10.1007/bf01805942 · Cited by 172 · see citing works

Control of secretion and the function of C19-Δ5-steroids of the human adrenal gland

Adams, J. B. (1985) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(85)90138-8 · Cited by 161 · see citing works

Biology and mode of action of pure antioestrogens.

Wakeling, A. E., & Bowler, J. (1988) · PubMed · doi:10.1016/0022-4731(88)90086-6 · Cited by 150 · see citing works

Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice

Black, L. J., & Goode, R. L. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90049-1 · Cited by 134 · see citing works

Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumour flare

Reddel, R. R., & Sutherland, R. L. (1984) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(84)90062-2 · Cited by 123 · see citing works

New biospecific adsorbents for the purification of estradiol receptor.

Bucourt, R., Vignau, M., & TORELLI, V. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34385-5 · Cited by 121 · see citing works

Apparent Positive Cooperative Effects in Cyclic AMP and Corticosterone Production by Isolated Adrenal Cells in Response to ACTH Analogues

Rodbard, D. (1974) · Endocrinology · doi:10.1210/endo-94-5-1427 · Cited by 116 · see citing works

An Exact Correction to the “Cheng-Prusoff” Correction

Munson, P. J., & Rodbard, D. (1988) · Journal of Receptor Research · doi:10.3109/10799898809049010 · Cited by 110 · see citing works

Estrogen receptor-mediated and cytotoxic effects of the antiestrogens tamoxifen and 4-hydroxytamoxifen.

Taylor, C. M., Blanchard, B., & Zava, D. T. (1984) · PubMed · Cited by 100 · see citing works

Mechanisms of oestrogen antagonism by nonsteroidal antioestrogens

Sutherland, R. L., & Murphy, L. C. (1982) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(82)90165-4 · Cited by 97 · see citing works

Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells.

Gulino, A., Barrera, G., Vacca, A., et al. (1986) · PubMed · Cited by 89 · see citing works

Human Breast Cancer: Biologically Active Estrogen Receptor in the Absence of Estrogen?

Zava, D. T., Chamness, G. C., Horwitz, K. B., et al. (1977) · Science · doi:10.1126/science.193182 · Cited by 85 · see citing works

A simple method to determine whole cell uptake of radiolabelled oestrogen and progesterone and their subcellular localization in breast cancer cell lines in monolayer culture

Taylor, C. M., Blanchard, B., & Zava, D. T. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90347-9 · Cited by 80 · see citing works

Calcium channel antagonist properties of the antineoplastic antiestrogen tamoxifen in the PC12 neurosecretory cell line.

Greenberg, D. A., Carpenter, C. L., & Messing, R. O. (1987) · PubMed · Cited by 77 · see citing works

The antiproliferative effect of tamoxifen in breast cancer cells: mediation by the estrogen receptor

Bardon, S., Vignon, F., Derocq, D., et al. (1984) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(84)90004-2 · Cited by 72 · see citing works

11beta-Methoxy-17-ethynyl-1,3,5(10)-estratriene-3,17beta-diol (moxestrol), a tag for estrogen receptor binding sites in human tissues.

Raynaud, J., Martin, P., Bouton, M.-M., et al. (1978) · PubMed · Cited by 60 · see citing works

Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture.

Osborne, C. K., Monaco, M. E., Kahn, C. R., et al. (1979) · PubMed · Cited by 57 · see citing works

Biological markers for breast carcinoma

Waalkes, T. P., Enterline, J. P., Shaper, J. H., Abeloff, M. D., & Ettinger, D. S. (1984) · Cancer · doi:10.1002/1097-0142(19840201)53:3+ · Cited by 49 · see citing works

Definition of two distinct mechanisms of action of antiestrogens on human breast cancer cell proliferation using hydroxytriphenylethylenes with high affinity for the estrogen receptor

Sutherland, R. L., Watts, C. K. W., & Ruenitz, P. C. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90763-1 · Cited by 48 · see citing works

An evaluation of tamoxifen as a partial agonist by classical receptor theory — An explanation of the dual action of tamoxifen

MacNab, M. W., Tallarida, R. J., & Joseph, R. R. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90493-x · Cited by 47 · see citing works

Estrogen and antiestrogen interaction with estrogen receptor of MCF-7 cells—Relationship between processing and estrogenicity

Gyling, M., & Leclercq, G. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90368-8 · Cited by 41 · see citing works

Competitive binding assay for estrogen receptor in monolayer culture: Measure of receptor activation potency

Stoessel, S., & Leclercq, G. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90010-5 · Cited by 40 · see citing works

Keoxifene shows pure antiestrogenic activity in pituitary gonadotrophs

Simard, J., & Labrie, F. (1985) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(85)90131-5 · Cited by 33 · see citing works

A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells.

Kasid, A., Strobl, J. S., Huff, K., Greene, G. L., & Lippman, M. E. (1984) · Science · doi:10.1126/science.6474170 · Cited by 32 · see citing works

Kinetic Alterations in Estrogen Receptors Associated with Estrogen Receptor Processing in Human Breast Cancer Cells*

Strobl, J. S., Kasid, A., Huff, K. K., et al. (1984) · Endocrinology · doi:10.1210/endo-115-3-1116 · Cited by 29 · see citing works

Fundamental research leading to improved endocrine therapy for breast cancer

Miller, W. R. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90343-8 · Cited by 16 · see citing works

Estrogenic effect of tamoxifen and its derivatives on the proliferation of MCF7 human breast tumor cells

Sonnenschein, C., Papendorp, J. T., & Soto, A. M. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90510-7 · Cited by 12 · see citing works

Biochemical and biological aspects of anti-oestrogen action

Wakeling, A. E., & Slater, S. R. (1981) · doi:10.1007/978-1-349-81345-2_12 · Cited by 12 · see citing works

MECHANISMS OF HORMONE ACTION

Stanley, J. C. (1981) · British Journal of Anaesthesia · doi:10.1093/bja/53.2.147 · Cited by 10 · see citing works

Estrogens and antiestrogens mediate contrasting transitions in estrogen receptor conformation which determine chromatin access: a review and synthesis of recent observations.

Nelson, K., van Nagell, J. R., Gallion, H. H., et al. (1988) · PubMed · Cited by 2 · see citing works

Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone

Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works

Intracrinology: Role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease

Labrie, F., Luu-The, V, Lin, S., Simard, J., Labrie, C., El-Alfy, M., Pelletier, G., & Belanger, A. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250001 · Cited by 278 · see citing works

Down-regulation of estrogen receptors by androgens in the ZR-75-1 human breast cancer cell line.

POULIN, R., SIMARD, J., LABRIE, C., PETITCLERC, L., DUMONT, M., LAGACÉ, L., & LABRIE, F. (1989) · Endocrinology · doi:10.1210/endo-125-1-392 · Cited by 115 · see citing works

The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth

Osborne, C. K., Jarman, M., McCague, R., et al. (1994) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00685924 · Cited by 132 · see citing works

The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth

Coronado, E. B., Hilsenbeck, S. G., Wakeling, A. E., et al. (1994) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050111 · Cited by 9 · see citing works

Effects of a new clinically relevant antiestrogen (GW5638) related to tamoxifen on breast and endometrial cancer growth in vivo.

Dardes, R. C., O'Regan, R. M., Gajdos, C., et al. (2002) · PubMed · Cited by 37 · see citing works

Tamoxifen (Antiestrogen) Therapy in Advanced Breast Cancer

Kiang, D. T., & KENNEDY, B. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-6-687 · Cited by 168 · see citing works

[Breast cancer--tamoxifen and tamoxifen analogues for the treatment of breast cancer].

Iino, Y., & Morishita, Y. (1994) · PubMed