The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation
Abstract
The chromosomal breakpoint of chronic lymphocytic leukemia (CLL) cells of the B-cell type carrying the translocated long arms of chromosomes 11 and 14 [t(11;14) (q13;q32)] was cloned. The breakpoint was found to be within the joining segment of the human heavy chain locus on the translocated long arm of chromosome 14. A probe that is specific for chromosome 11 and that maps immediately 5′ to the breakpoint on the 14q + chromosome was isolated. The probe detected a rearrangement of the homologous genomic DNA segment in the parental CLL cells and also in DNA from a diffuse large cell lymphoma with the t(11;14) translocation. This rearranged DNA segment was not present in Burkitt lymphoma cells with the t(8;14) translocation or in nonneoplastic human lymphoblastoid cells. The probe can thus be used to identify and characterize a gene located on band q13 of chromosome 11 that appears to be involved in the malignant transformation of human B cells carrying the t(11;14) translocation. This gene, named bcl-1 , appears to be unrelated to any of the known retrovirus oncogenes described to date.
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Citations
Cites
Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus
Mercola, M., Wang, X.-F., Olsen, J., & Calame, K. (1983) · Science · doi:10.1126/science.6306772 · Cited by 152
Cited by
Tsujimoto, Y., Finger, L. R., Yunis, J., Nowell, P. C., & Croce, C. M. (1984) · Science · doi:10.1126/science.6093263 · Cited by 1,769
Self-citationTreating cancer with selective CDK4/6 inhibitors
O'Leary, B., Finn, R. S., & Turner, N. C. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.26 · Cited by 1,137
Croce, C. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072367 · Cited by 1,055
Self-citationTsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E., & Croce, C. M. (1985) · Science · doi:10.1126/science.3929382 · Cited by 991
Self-citationFrom basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
Ashkenazi, A., Fairbrother, W. J., Leverson, J. D., & Souers, A. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.253 · Cited by 903
Metadata
- Authors
- Tsujimoto, Y., Yunis, J., Onorato-Showe, L., Erikson, J., Nowell, P. C., & Croce, C. M.
- Venue
- Science
- Published
- 1984-06-29
- Volume
- 224
- Issue
- 4656
- Pages
- 1403-1406
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082030057
- Cited by
- 652
- References
- 1
- FWCI
- 28.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tsujimoto, Y., Yunis, J., Onorato-Showe, L., Erikson, J., Nowell, P. C., & Croce, C. M. (1984). Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation. Science. https://doi.org/10.1126/science.6610211
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
