Cited by 195Cerebrospinal fluid and hydrocephalusIon Transport and Channel RegulationTraumatic Brain Injury and Neurovascular Disturbances

Sympathetic nervous control of cerebrospinal fluid production from the choroid plexus

Lindvall, Maria, Edvinsson, Lars, Owman, Christer·1978·Science

Abstract

The rabbit choroid plexus, responsible for the bulk production of cerebrospinal fluid, is well supplied by sympathetic nerves emanating in the superior cervical ganglia. Electrical stimulation of these nerves markedly reduces production of cerebrospinal fluid, measured by [14C] inulin dilution during ventricular perfusion, whereas sympathetic denervation enhances the rate of formation.

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Crossref · 10.1126/science.663649

Cites

17 of 17 references verified0 citation errors · 0 not checkable

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  • Neuronal and glia-like cells were captured in the ChP across all ages, validated by immunostaining.

    “We captured neuronal (Tubb3 expressing) and glia-like (Slc1a3/EAAT1 or GFAP expressing) cells in the ChP across all ages, validated by immunostaining (Figures 1C,D,I, S1J-L), in agreement with previous studies (Lindvall et al., 1978).”

    From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Lindvall et al., 1978

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Authors
Lindvall, M., Edvinsson, L., & Owman, C.
Affiliations
Lund University (SE)
Venue
Science
Published
1978-07-14
Volume
201
Issue
4351
Pages
176-178
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2037918689
Cited by
195
References
17
Citations by year
2026: 2 · 2025: 7 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 5 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
3.77
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
cerebrospinal fluid production, choroid plexus, sympathetic nervous system, superior cervical ganglion, sympathetic denervation, electrical nerve stimulation, rabbits
MeSH terms
Adrenergic Fibers, Animals, Cerebrospinal Fluid, Choroid Plexus, Epithelium, Female, Ganglia, Autonomic, Male, Neural Pathways, Rabbits, Sympathetic Nervous System

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