Sympathetic nervous control of cerebrospinal fluid production from the choroid plexus
Abstract
The rabbit choroid plexus, responsible for the bulk production of cerebrospinal fluid, is well supplied by sympathetic nerves emanating in the superior cervical ganglia. Electrical stimulation of these nerves markedly reduces production of cerebrospinal fluid, measured by [14C] inulin dilution during ventricular perfusion, whereas sympathetic denervation enhances the rate of formation.
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Neuronal and glia-like cells were captured in the ChP across all ages, validated by immunostaining.
“We captured neuronal (Tubb3 expressing) and glia-like (Slc1a3/EAAT1 or GFAP expressing) cells in the ChP across all ages, validated by immunostaining (Figures 1C,D,I, S1J-L), in agreement with previous studies (Lindvall et al., 1978).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Lindvall et al., 1978
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Self-citationChoroid plexus blood flow: evidence for dopaminergic influence
Townsend, J. B., Ziedonis, D. M., Bryan, R. M., Brennan, R. W., & Page, R. B. (1984) · Brain Research · doi:10.1016/0006-8993(84)90748-0 · Cited by 22 · see citing works
Friedman, D. I. (1999) · Neurosurgery Clinics of North America · doi:10.1016/s1042-3680(18)30161-x · Cited by 22 · see citing works
Lindvall, M. L., & Owman, C. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb11175.x · Cited by 21 · see citing works
Self-citationSharma, R. P., Javaid, J. I., Faull, K. F., Davis, J. M., & Janicak, P. G. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90046-9 · Cited by 20 · see citing works
Cerebral fluid overproduction in the absence of tumor or villous hypertrophy of the choroid plexus
Casey, K. F., & Vries, J. K. (1989) · Child s Nervous System · doi:10.1007/bf00274525 · Cited by 20 · see citing works
Choroid plexus blood flow in the sheep
Page, R. B., Funsch, D. J., Brennan, R. W., & Hernández, M. J. (1980) · Brain Research · doi:10.1016/0006-8993(80)91142-7 · Cited by 20 · see citing works
Lindvall, M., & Owman, C. (1984) · Experimental Neurology · doi:10.1016/0014-4886(84)90208-5 · Cited by 19 · see citing works
Self-citationH2 Histamine Receptors on the Epithelial Cells of Choroid Plexus
Crook, R. B., Farber, M. B., & Prusiner, S. B. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb12994.x · Cited by 18 · see citing works
Pershing, L. K., & Johanson, C. E. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb08632.x · Cited by 18 · see citing works
- Authors
- Lindvall, M., Edvinsson, L., & Owman, C.
- Affiliations
- Lund University (SE)
- ORCID
- Edvinsson, Lars
- Venue
- Science
- Published
- 1978-07-14
- Volume
- 201
- Issue
- 4351
- Pages
- 176-178
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037918689
- Cited by
- 195
- References
- 17
- Citations by year
- 2026: 2 · 2025: 7 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 5 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- cerebrospinal fluid production, choroid plexus, sympathetic nervous system, superior cervical ganglion, sympathetic denervation, electrical nerve stimulation, rabbits
- MeSH terms
- Adrenergic Fibers, Animals, Cerebrospinal Fluid, Choroid Plexus, Epithelium, Female, Ganglia, Autonomic, Male, Neural Pathways, Rabbits, Sympathetic Nervous System
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