Cited by 750Marine Sponges and Natural ProductsToxin Mechanisms and ImmunotoxinsIsoquinoline Alkaloid Synthesis

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Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells

Spector, Ilan, Shochet, Nava R., Kashman, Yoel, Groweiss, Amiram·1983·Science

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Abstract

Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red Sea sponge Latrunculia magnifica. The effects of these toxins on cultured mouse neuroblastoma and fibroblast cells have been evaluated. In both types of cells, submicromolar toxin concentrations rapidly induce striking changes in cell morphology that are reversible upon removal of the toxin. Immunofluorescence studies with antibodies specific for cytoskeletal proteins reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organization of the microtubular system.

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Authors: Spector, I., Shochet, N. R., Kashman, Y., & Groweiss, A.
Affiliations: National Institutes of Health (US)
Tel Aviv University (IL)
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1983-02-04
Volume: 219
Issue: 4584
Pages: 493-495
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.6681676
OpenAlex: W1984653721
Cited by: 750
References: 21
Citations by year: 2026: 18 · 2025: 22 · 2024: 16 · 2023: 21 · 2022: 16 · 2021: 19 · 2020: 31 · 2019: 21 · 2018: 19 · 2017: 16 · 2016: 19 · 2015: 28 · 2014: 33 · 2013: 31 · 2012: 29
FWCI: 5.40
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
Life Sciences › Immunology and Microbiology › Immunology › Toxin Mechanisms and Immunotoxins
Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
Keywords: latrunculin, latrunculin A, latrunculin B, marine toxins, marine sponges, microfilament organization, actin cytoskeleton, macrolides, neuroblastoma cells, fibroblasts, cell morphology, microtubules
MeSH terms: Actins, Animals, Cells, Cultured, Cytoskeleton, Fibroblasts, Marine Toxins, Microscopy, Fluorescence, Microtubules, Neuroblastoma, Thiazoles, Bridged Bicyclo Compounds, Heterocyclic, Thiazolidines

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Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells

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