The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells
Abstract
Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red Sea sponge Latrunculia magnifica. The effects of these toxins on cultured mouse neuroblastoma and fibroblast cells have been evaluated. In both types of cells, submicromolar toxin concentrations rapidly induce striking changes in cell morphology that are reversible upon removal of the toxin. Immunofluorescence studies with antibodies specific for cytoskeletal proteins reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organization of the microtubular system.
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“When neurons are treated with Latrunculin A, which sequesters monomeric actin (G-actin) and perturbs F-actin formation12,13, ultrafast endocytosis fails completely, with no induction of membrane pit formation5.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [13]
Citations
Cites
Mechanism of action of cytochalasin B on actin
MacLean-Fletcher, S. (1980) · Cell · doi:10.1016/0092-8674(80)90619-4 · Cited by 755
Clarke, M., & Spudich, J. A. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004053 · Cited by 504
Actin-binding proteins—regulators of cell architecture and motility
Weeds, A. G. (1982) · Nature · doi:10.1038/296811a0 · Cited by 467
Cytoplasmic fibrils in living cultured cells
Buckley, I. K., & Porter, K. R. (1967) · PROTOPLASMA · doi:10.1007/bf01666538 · Cited by 354
Yahara, I., Harada, F., Sekita, S., Yoshihira, K., & Natori, S. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.92.1.69 · Cited by 321
Cytochalasin inhibits the rate of elongation of actin filament fragments
Brown, S. S., & Spudich, J. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.83.3.657 · Cited by 297
Brenner, S. L., & Korn, E. D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86660-7 · Cited by 266
Mechanism of action of cytochalasin: evidence that it binds to actin filament ends.
Brown, S. S., & Spudich, J. A. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.88.3.487 · Cited by 262
Cytochalasin B and the structure of actin gels
Hartwig, J. H., & Stossel, T. P. (1979) · Journal of Molecular Biology · doi:10.1016/0022-2836(79)90366-8 · Cited by 236
The distribution of actin in non-muscle cells
Goldman, R. D., Lazarides, E., Pollack, R., & Weber, K. (1975) · Experimental Cell Research · doi:10.1016/0014-4827(75)90323-7 · Cited by 221
Cytoplasmic contractile proteins.
Pollard, T. D. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.3.156s · Cited by 197
Ionic currents in cultured mouse neuroblastoma cells under voltage‐clamp conditions.
Moolenaar, W. H., & Spector, I. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012303 · Cited by 175
Self-citationLatrunculin, a new 2-thiazolidinone macrolide from the marine sponge
Kashman, Y., Groweiss, A., & Shmueli, U. (1980) · Tetrahedron Letters · doi:10.1016/0040-4039(80)80255-3 · Cited by 164
Self-citationExcitable Cells in Tissue Culture
(1981) · Springer eBooks · doi:10.1007/978-1-4684-3803-1 · Cited by 143
Lin, D. C., & Lin, S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.5.2345 · Cited by 120
Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells
Spiegelman, B. M., Lopata, M. A., & Kirschner, M. W. (1979) · Cell · doi:10.1016/0092-8674(79)90003-5 · Cited by 116
Multiple sites for the initiation of microtubule assembly in mammalian cells
Spiegelman, B. M., Lopata, M. A., & Kirschner, M. W. (1979) · Cell · doi:10.1016/0092-8674(79)90002-3 · Cited by 99
Isolation of a new toxin from the sponge Latrunculia magnifica in the Gulf of Aquaba (Red Sea)
N�eman, I., Fishelson, L., & Kashman, Y. (1975) · Marine Biology · doi:10.1007/bf00390634 · Cited by 53
Self-citationAllen, R. D. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.3.148s · Cited by 44
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Marchisio, P. C., Osborn, M., & Weber, K. K. (1978) · Journal of Neurocytology · doi:10.1007/bf01260890 · Cited by 25
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Research works printed but not linked: 1
- Marchisio, P. C., Tissue Culture in Neurobiology: 99 (1980).
Cited by
Sorted by citations
Galliford, C. V., & Scheidt, K. A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200701342 · Cited by 2,441
Rotsch, C., & Radmacher, M. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76614-8 · Cited by 972
Inhibition of actin polymerization by latrunculin A
Coué, M., Brenner, S. L., Spector, I., & Korn, E. D. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81513-2 · Cited by 824
Self-citationDivergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils
Xu, J., Wang, F., Keymeulen, A. V., Herzmark, P., Straight, A. F., Kelly, K., Takuwa, Y., Sugimoto, N., Mitchison, T. J., & Bourne, H. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00555-5 · Cited by 684
Ultrafast endocytosis at mouse hippocampal synapses
Watanabe, S., Rost, B. R., Camacho-Pérez, M., Davis, M. W., Söhl-Kielczynski, B., Rosenmund, C., & Jorgensen, E. M. (2013) · Nature · doi:10.1038/nature12809 · Cited by 607
Metadata
- Authors
- Spector, I., Shochet, N. R., Kashman, Y., & Groweiss, A.
- Affiliations
- National Institutes of Health (US)
- Tel Aviv University (IL)
- Venue
- Science
- Published
- 1983-02-04
- Volume
- 219
- Issue
- 4584
- Pages
- 493-495
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984653721
- Cited by
- 750
- References
- 21
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 16 · 2023: 21 · 2022: 16 · 2021: 19 · 2020: 31 · 2019: 21 · 2018: 19 · 2017: 16 · 2016: 19 · 2015: 28 · 2014: 33 · 2013: 31 · 2012: 29
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Immunology and Microbiology › Immunology › Toxin Mechanisms and Immunotoxins
- Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
- Keywords
- latrunculin, latrunculin A, latrunculin B, marine toxins, marine sponges, microfilament organization, actin cytoskeleton, macrolides, neuroblastoma cells, fibroblasts, cell morphology, microtubules
- MeSH terms
- Actins, Animals, Cells, Cultured, Cytoskeleton, Fibroblasts, Marine Toxins, Microscopy, Fluorescence, Microtubules, Neuroblastoma, Thiazoles, Bridged Bicyclo Compounds, Heterocyclic, Thiazolidines
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