The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity
Abstract
The cytotoxic activity of natural killer cells was investigated in rats subjected to one of two inescapable footshock stress paradigms, both of which induce analgesia, but only one via activation of opioid mechanisms. Splenic natural killer cell activity was suppressed by the opioid, but not the nonopioid, form of stress. This suppression was blocked by the opioid antagonist naltrexone. Similar suppression of natural killer activity was induced by high doses of morphine. These results suggest that endogenous opioid peptides mediate the suppressive effect of certain forms of stress on natural killer cell cytotoxicity.
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Cites
Behavioural despair in rats: A new model sensitive to antidepressant treatments
Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138
Learned helplessness: Theory and evidence
Maier, S. F., & Seligman, M. E. (1976) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.105.1.3 · Cited by 2,494
Sklar, L. S., & Anisman, H. (1981) · Psychological Bulletin · doi:10.1037/0033-2909.89.3.369 · Cited by 288
Cited by
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902
Psychological Stress and Susceptibility to the Common Cold
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108293250903 · Cited by 1,712
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Stress and immunity: An integrated view of relationships between the brain and the immune system
Dantzer, R., & Kelley, K. W. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90345-7 · Cited by 534
Restraint stress in biomedical research: An update
Glavin, G. B., Paré, W. P., Sandbak, T., Bakke, H.-K., & Murison, R. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90027-2 · Cited by 304
Metadata
- Authors
- Shavit, Y., Lewis, J. W., Terman, G. W., Gale, R. P., & Liebeskind, J. C.
- Venue
- Science
- Published
- 1984-01-13
- Volume
- 223
- Issue
- 4632
- Pages
- 188-190
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997619239
- Cited by
- 602
- References
- 3
- FWCI
- 17.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity. https://app.cochat.ai/papers/10.1126/science.6691146
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- Shavit, Y., Lewis, J. W., Terman, G. W., Gale, R. P., & Liebeskind, J. C. (1984). Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity. Science. https://doi.org/10.1126/science.6691146
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
