The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound
Abstract
Benzoyl peroxide, a widely used free radical-generating compound, promoted both papillomas and carcinomas when it was topically applied to mice after 7,12-dimethylbenz[ a ]anthracene initiation. Benzoyl peroxide was inactive on the skin as a complete carcinogen or as a tumor initiator. A single topical application of benzoyl peroxide produced a marked epidermal hyperplasia and induced a large number of dark basal keratinocytes, effects similar to those produced by the potent tumor promoter 12- O -tetradecanoyl phorbol-13-acetate. Benzoyl peroxide, like other known tumor promoters, also inhibited metabolic cooperation (intercellular communication) in Chinese hamster cells. In view of these results caution should be recommended in the use of this and other free radical-generating compounds.
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Citations
Cites
Some Biological Aspects of Skin Carcinogenesis*
Boutwell, R. K. (2015) · Progress in Tumor Research · doi:10.1159/000385978 · Cited by 623
Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents.
O’Brien, T. G., Simsiman, R. C., & Boutwell, R. K. (1975) · PubMed · Cited by 495
Specific binding of phorbol ester tumor promoters
Driedger, P. E., & Blumberg, P. M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.1.567 · Cited by 360
Inhibition of Chemical Carcinogenesis
Wattenberg, L. W. (1978) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/60.1.11 · Cited by 314
The stimulation of phospholipid metabolism in mouse skin following phorbol ester treatment
Rohrschneider, L. R., O'Brien, D., & Boutwell, R. K. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90212-3 · Cited by 109
Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol
Slaga, T. J., Viaje, A., Berry, D. L., Bracken, W. M., Buty, S. G., & Scribner, J. D. (1976) · Cancer Letters · doi:10.1016/s0304-3835(76)80020-1 · Cited by 107
Self-citationTumor Initiation by Apparently Noncarcinogenic Polycyclic Aromatic Hydrocarbons2
Scribner, J. D. (1973) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/50.6.1717 · Cited by 83
Kensler, T. W., & Trush, M. A. (1981) · PubMed · Cited by 82
Cited by
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441
Antioxidant Activity of Various Tea Extracts in Relation to Their Antimutagenicity
Yen, G.-C., & Chen, H.-Y. (1995) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00049a007 · Cited by 2,629
Free-radical chemistry of cigarette smoke and its toxicological implications.
Church, D. F., & Pryor, W. A. (1985) · Environmental Health Perspectives · doi:10.1289/ehp.8564111 · Cited by 1,441
Reactive oxygen species in tumor progression
Storz, P. (2005) · Frontiers in Bioscience · doi:10.2741/1667 · Cited by 957
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
Metadata
- Authors
- Slaga, T. J., Klein-Szanto, A. J. P., Triplett, L. L., Yotti, L. P., & Trosko, J. E.
- Venue
- Science
- Published
- 1981-08-28
- Volume
- 213
- Issue
- 4511
- Pages
- 1023-1025
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088039859
- Cited by
- 502
- References
- 8
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Slaga, T. J., Klein-Szanto, A. J. P., Triplett, L. L., Yotti, L. P., & Trosko, J. E. (1981). Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound. Science. https://doi.org/10.1126/science.6791284
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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