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DNA Methylation Decreases in Aging But Not in Immortal Cells
Abstract
When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of divisions. Immortal mouse cell lines had more stable rates of methylation.
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Citations
Cited by
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Epigenetics in human disease and prospects for epigenetic therapy
Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232
Self-citationChristman, J. K. (2002) · Oncogene · doi:10.1038/sj.onc.1205699 · Cited by 1,525
The Inheritance of Epigenetic Defects
Holliday, R. (1987) · Science · doi:10.1126/science.3310230 · Cited by 1,082
DNA methylation aging clocks: challenges and recommendations
Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology · doi:10.1186/s13059-019-1824-y · Cited by 1,025
Metadata
- Authors
- Wilson, V. L., & Jones, P. A.
- Venue
- Science
- Published
- 1983-06-03
- Volume
- 220
- Issue
- 4601
- Pages
- 1055-1057
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987793414
- Cited by
- 645
- References
- 0
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wilson, V. L., & Jones, P. A. (1983). DNA Methylation Decreases in Aging But Not in Immortal Cells. Science. https://doi.org/10.1126/science.6844925
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
