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Nuclear Transplantation in the Mouse Embryo by Microsurgery and Cell Fusion
Abstract
Nuclear transplantation in the mouse embryo was achieved by using a method that combines microsurgical removal of the zygote pronuclei with the introduction of a donor nucleus by a virus-mediated cell fusion technique. Survival of embryos was greater than 90 percent in tests of this procedure. The embryos developed to term at a frequency not significantly different from that of nonmanipulated control embryos. Because nuclei and cytoplasm from genetically distinct inbred mouse strains can be efficiently interchanged, this procedure may be useful in characterizing possible cytoplasmic contributions to the embryonic and adult phenotype.
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Cited by
Cloned pigs produced by nuclear transfer from adult somatic cells
Polejaeva, I. A., Chen, S.-H., Vaught, T. D., Page, R. L., Mullins, J., Ball, S., Dai, Y., Boone, J., Walker, S., Ayares, D. L., et al. (2000) · Nature · doi:10.1038/35024082 · Cited by 1,254
Role of paternal and maternal genomes in mouse development
Barton, S. C., Surani, M. A. H., & Norris, M. L. (1984) · Nature · doi:10.1038/311374a0 · Cited by 724
Jenuth, J. P., Peterson, A. C., Fu, K., & Shoubridge, E. A. (1996) · Nature Genetics · doi:10.1038/ng1096-146 · Cited by 591
Genomic Imprinting and Physiological Processes in Mammals
Tucci, V., Isles, A. R., Kelsey, G., Ferguson-Smith, A. C., Tucci, V., Bartolomei, M. S., Benvenisty, N., Bourc’his, D., Charalambous, M., Dulac, C., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.043 · Cited by 544
Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice
Jenuth, J. P., Peterson, A. C., & Shoubridge, E. A. (1997) · Nature Genetics · doi:10.1038/ng0597-93 · Cited by 415
Metadata
- Authors
- McGrath, J., & Solter, D.
- Venue
- Science
- Published
- 1983-06-17
- Volume
- 220
- Issue
- 4603
- Pages
- 1300-1302
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050384177
- Cited by
- 589
- References
- 0
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- McGrath, J., & Solter, D. (1983). Nuclear Transplantation in the Mouse Embryo by Microsurgery and Cell Fusion. Science. https://doi.org/10.1126/science.6857250
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
