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Chromosomal Mosaicism Confined to the Placenta in Human Conceptions
Abstract
Placental and fetal tissues from 46 human pregnancies were cultured and cytogenetically analyzed in an attempt to document the existence of chromosomal mosaicism confined strictly to tissues of extraembryonic origin. In two gestations in which chromosomal mosaicism was found, it was expressed exclusively in placental chorionic cells and was not detected in cells derived from the embryo proper. This demonstration of confined chorionic mosaicism may have implications for the understanding of the fetoplacental unit and for prenatal diagnosis.
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Cited by
Capalbo, A., Poli, M., Rienzi, L., Girardi, L., Patassini, C., Fabiani, M., Cimadomo, D., Benini, F., Farcomeni, A., Cuzzi, J., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.11.002 · Cited by 269
Aetiology and pathogenesis of IUGR
Sankaran, S., & Kyle, P. M. (2009) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2009.05.003 · Cited by 210
Metadata
- Authors
- Kalousek, D. K., & Dill, F. J.
- Venue
- Science
- Published
- 1983-08-12
- Volume
- 221
- Issue
- 4611
- Pages
- 665-667
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008478368
- Cited by
- 394
- References
- 0
- FWCI
- 21.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kalousek, D. K., & Dill, F. J. (1983). Chromosomal Mosaicism Confined to the Placenta in Human Conceptions. Science. https://doi.org/10.1126/science.6867735
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.