The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial
Open accessAbstract
Chromosome imbalance (aneuploidy) is the major cause of pregnancy loss and congenital disorders in humans. Analyses of small biopsies from human embryos suggest that aneuploidy commonly originates during early divisions, resulting in mosaicism. However, the developmental potential of mosaic embryos remains unclear. We followed the distribution of aneuploid chromosomes across 73 unselected preimplantation embryos and 365 biopsies, sampled from four multifocal trophectoderm (TE) samples and the inner cell mass (ICM). When mosaicism impacted fewer than 50% of cells in one TE biopsy (low-medium mosaicism), only 1% of aneuploidies affected other portions of the embryo. A double-blinded prospective non-selection trial (NCT03673592) showed equivalent live-birth rates and miscarriage rates across 484 euploid, 282 low-grade mosaic, and 131 medium-grade mosaic embryos. No instances of mosaicism or uniparental disomy were detected in the ensuing pregnancies or newborns, and obstetrical and neonatal outcomes were similar between the study groups. Thus, low-medium mosaicism in the trophectoderm mostly arises after TE and ICM differentiation, and such embryos have equivalent developmental potential as fully euploid ones.
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Cites
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Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts
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Self-citationTransfer of Fresh versus Frozen Embryos in Ovulatory Women
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Chromosome errors in human eggs shape natural fertility over reproductive life span
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Chromosomal Mosaicism Confined to the Placenta in Human Conceptions
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Chromosomal mosaicism in human preimplantation embryos: a systematic review
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Metadata
- Authors
- Capalbo, A., Poli, M., Rienzi, L., Girardi, L., Patassini, C., Fabiani, M., Cimadomo, D., Benini, F., Farcomeni, A., Cuzzi, J., Rubio, C., Albani, E., Sacchi, L., Vaiarelli, A., Figliuzzi, M., Findikli, N., Coban, O., Boynukalin, F. K., Vogel, I., Hoffmann, E., Livi, C., Levi-Setti, P. E., Ubaldi, F. M., & Simón, C.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 108
- Issue
- 12
- Pages
- 2238-2247
- ISSN
- 0002-9297 (ISSN-L)
- OpenAlex
- W3214571675
- Cited by
- 269
- References
- 23
- FWCI
- 38.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Capalbo, A., Poli, M., Rienzi, L., Girardi, L., Patassini, C., Fabiani, M., Cimadomo, D., Benini, F., Farcomeni, A., Cuzzi, J., Rubio, C., Albani, E., Sacchi, L., Vaiarelli, A., Figliuzzi, M., Findikli, N., Coban, O., Boynukalin, F. K., Vogel, I., . . . Simón, C. (2021). Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial. The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2021.11.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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