The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Aged Rats: Recovery of Motor Impairments by Intrastriatal Nigral Grafts
Abstract
Dissociated cell suspensions, prepared from the substantia nigra and septal regions of rat embryos, can be grafted to the depths of the caudate-putamen and hippocampus of aged rats. The grafts were rich in dopamine-containing and acetylcholinesterase-positive neurons and had produced extensive new dopaminergic and cholinergic terminal networks in the host neostriatum and hippocampus, respectively. The intrastriatal dopaminergic grafts were associated with a significant improvement in motor coordination in the aged rats. This result suggests that the intracerebral grafting technique may provide a new tool for exploring the role of dopaminergic and cholinergic deficits in the neurological and behavioral impairments associated with aging.
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Citations
Cites
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Hippocampus, space, and memory
Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00062713 · Cited by 2,018
Bartus, R. T., Dean, R. L., Sherman, K. A., Friedman, E., & Beer, B. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90007-5 · Cited by 140
Cited by
Multipotent neural cell lines can engraft and participate in development of mouse cerebellum
Snyder, E. Y., Deitcher, D. L., Walsh, C., Arnold-Aldea, S., Hartwieg, E. A., & Cepko, C. L. (1992) · Cell · doi:10.1016/0092-8674(92)90204-p · Cited by 915
Brundin, P., Strecker, R. E., Widner, H., Clarke, D. J., Nilsson, O. G., Åstedt, B., Lindvall, O., & Björklund, A. (1988) · Experimental Brain Research · doi:10.1007/bf00271860 · Cited by 278
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Metadata
- Authors
- Gage, F. H., Dunnett, S. B., Stenevi, U., & Björklund, A.
- Venue
- Science
- Published
- 1983-09-02
- Volume
- 221
- Issue
- 4614
- Pages
- 966-969
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048951599
- Cited by
- 160
- References
- 3
- FWCI
- 18.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gage, F. H., Dunnett, S. B., Stenevi, U., & Björklund, A. (1983). Aged Rats: Recovery of Motor Impairments by Intrastriatal Nigral Grafts. Science. https://doi.org/10.1126/science.6879196
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
