The DOI matches its Crossref record.
Genetic Diversity and Structure in Escherichia coli Populations
Abstract
A survey of electrophoretic variation in 20 enzymes from 109 clones of Escherichia coli from natural populations yielded an estimate of mean genetic diversity approximately twice that reported in an earlier study and four to five times larger than estimates for most eukaryotic species. Despite this extensive variability, the number of distinctive genotypes apparently is rather limited. Identical clones were obtained from unassociated hosts, and a clone that is electrophoretically indistinguishable from the laboratory strain Escherichia coli K-12 was isolated from a human infant. The results suggest that rates of genetic recombination in natural populations of Escherichia coli are low. These findings have implications for our understanding of the genetic structure of Escherichia coli populations and the factors determining the amount of neutral gene variability in this bacterial species.
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Cited by
Smith, J. M., Smith, N. H., O'Rourke, M., & Spratt, B. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4384 · Cited by 1,802
The Nearly Neutral Theory of Molecular Evolution
Ohta, T. (1992) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.23.110192.001403 · Cited by 1,149
Multilocus Sequence Typing of Bacteria
Maiden, M. C. J. (2006) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121325 · Cited by 915
The Link between Phylogeny and Virulence in Escherichia coli Extraintestinal Infection
Picard, B., Garcia, J. S., Gouriou, S., Duriez, P., Brahimi, N., Bingen, E., Elion, J., & Denamur, E. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.546-553.1999 · Cited by 794
Dykhuizen, D. E., & Hartl, D. L. (1983) · Microbiological Reviews · doi:10.1128/mmbr.47.2.150-168.1983 · Cited by 373
Metadata
- Authors
- Selander, R. K., & Levin, B. R.
- Venue
- Science
- Published
- 1980-10-31
- Volume
- 210
- Issue
- 4469
- Pages
- 545-547
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088330494
- Cited by
- 418
- References
- 0
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Selander, R. K., & Levin, B. R. (1980). Genetic Diversity and Structure in Escherichia coli Populations. Science. https://doi.org/10.1126/science.6999623
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