The Nearly Neutral Theory of Molecular Evolution
Abstract
Species distribution models (SDMs) are numerical tools that combine observations of species occurrence or abundance with environmental estimates. They are used to gain ecological and evolutionary insights and to predict distributions across landscapes, ...Read More
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Long-term small population size tends to lead to accumulation of weakly and moderately deleterious variation due to reduced efficacy of selection, but also removes strongly deleterious variation through genetic purging.
“long-term small population size tends to lead to the accumulation of weakly and moderately deleterious variation due to a reduced efficacy of selection,16,17 but it also removes strongly deleterious variations through genetic purging.18,19”
From Genomes of critically endangered saola are shaped by population structure and purging (2025) · cites this paper as [16]
The elevated relative amount of segregating potentially deleterious mutations in saola is expected due to a reduction in the efficiency of selection in small populations.
“which is expected due to a reduction in the efficiency of selection in small populations.16”
From Genomes of critically endangered saola are shaped by population structure and purging (2025) · cites this paper as [16]
Cites
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Slightly Deleterious Mutant Substitutions in Evolution
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Self-citationModel of effectively neutral mutations in which selective constraint is incorporated
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Zhang, J. (2000) · Journal of Molecular Evolution · doi:10.1007/s002399910007 · Cited by 356 · see citing works
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Genomes of critically endangered saola are shaped by population structure and purging
Garcia-Erill, G., Liu, S., Le, M. D., Hurley, M. M., Nguyen, H. D., Nguyen, D. Q., Nguyen, D. H., Santander, C. G., Sánchez Barreiro, F., Gomes Martins, N. F., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.040 · Cited by 10 · see citing works
- Authors
- Ohta, T.
- Corresponding author
- Ohta, Tomoko
- Venue
- Annual Review of Ecology and Systematics
- Publisher
- Annual Reviews
- Published
- 1992-11
- Volume
- 23
- Issue
- 1
- Pages
- 263-286
- ISSN
- 0066-4162 (ISSN-L)
- OpenAlex
- W2173518071
- Cited by
- 1,149
- References
- 3
- Citations by year
- 2026: 33 · 2025: 63 · 2024: 49 · 2023: 50 · 2022: 50 · 2021: 43 · 2020: 49 · 2019: 48 · 2018: 65 · 2017: 34 · 2016: 25 · 2015: 32 · 2014: 34 · 2013: 64 · 2012: 37
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Ecology and Systematics (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Keywords
- nearly neutral theory, molecular evolution, neutral theory, population genetics, genetic drift, mutation-selection balance
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