The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Blood-Brain Glucose Transfer: Repression in Chronic Hyperglycemia
Abstract
Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.
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“In rats with chronic hyperglycemia, the maximum glucose transport capacity of the BBB decreased from 400 to 290 micromoles per 100 grams per minute, and the glucose transport rate in the brain decreased to 20 percent below normal when plasma glucose was lowered to normal values [3].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [3]
In the citing paper
“On the other hand, repressive adaptation of glucose transport across the blood-brain-barrier (BBB) occurs in response to chronic hyperglycemia to prevent a rise in brain glucose content [3].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [3]
Citations
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Metadata
- Authors
- Gjedde, A., & Crone, C.
- Affiliations
- University of Copenhagen (DK)
- ORCID
- Gjedde, Albert
- Venue
- Science
- Published
- 1981-10-23
- Volume
- 214
- Issue
- 4519
- Pages
- 456-457
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091625139
- Cited by
- 235
- References
- 22
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- chronic hyperglycemia, glucose transport, blood-brain barrier, brain endothelial cells, plasma glucose, rats
- MeSH terms
- Animals, Biological Transport, Blood-Brain Barrier, Brain, Diabetes Mellitus, Experimental, Glucose, Hyperglycemia, Insulin, Kinetics, Regional Blood Flow, Rats
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