The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Wound Tissue Can Utilize a Polymeric Template to Synthesize a Functional Extension of Skin
Abstract
Prompt and long-term closure of full-thickness skin wounds in guinea pigs and humans is achieved by applying a bilayer polymeric membrane. The membrane comprises a top layer of a silicone elastomer and a bottom layer of a porous cross-linked network of collagen and glycosaminoglycan. The bottom layer can be seeded with a small number of autologous basal cells before grafting. No immunosuppression is used and infection, exudation, and rejection are absent. Host tissue utilizes the sterile membrane as a culture medium to synthesize neoepidermal and neodermal tissue. A functional extension of skin over the entire wound area is formed in about 4 weeks.
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Citations
Cites
Design of an artificial skin. Part III. Control of pore structure
Dagalakis, N., Flink, J., Stasikelis, P., Burke, J. F., & Yannas, I. V. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140417 · Cited by 358
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Cited by
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
A review of chitin and chitosan applications
Ravi Kumar, M. N. V. (2000) · Reactive and Functional Polymers · doi:10.1016/s1381-5148(00)00038-9 · Cited by 6,009
Collagen-Based Biomaterials for Tissue Engineering Applications
Parenteau-Bareil, R., Gauvin, R., & Berthod, F. (2010) · Materials · doi:10.3390/ma3031863 · Cited by 1,256
Collagen-based biomaterials for wound healing
Chattopadhyay, S., & Raines, R. T. (2014) · Biopolymers · doi:10.1002/bip.22486 · Cited by 1,041
Skin-inspired hydrogel–elastomer hybrids with robust interfaces and functional microstructures
Yuk, H., Zhang, T., Parada, G. A., Liu, X., & Zhao, X. (2016) · Nature Communications · doi:10.1038/ncomms12028 · Cited by 1,035
Metadata
- Authors
- Yannas, I. V., Burke, J. F., Orgill, D. P., & Skrabut, E. M.
- Venue
- Science
- Published
- 1982-01-08
- Volume
- 215
- Issue
- 4529
- Pages
- 174-176
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075339112
- Cited by
- 642
- References
- 1
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Wound Tissue Can Utilize a Polymeric Template to Synthesize a Functional Extension of Skin. https://app.cochat.ai/papers/10.1126/science.7031899
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- Yannas, I. V., Burke, J. F., Orgill, D. P., & Skrabut, E. M. (1982). Wound Tissue Can Utilize a Polymeric Template to Synthesize a Functional Extension of Skin. Science. https://doi.org/10.1126/science.7031899
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
