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Haptoglobin: A Natural Bacteriostat
Abstract
The combination of bacteria and blood in a wound can have lethal consequences, probably because hemoglobin iron supports prolific bacterial growth. Rats inoculated intraperitoneally with pathogenic Escherichia coli and small amounts of hemoglobin die. Simultaneous administration of haptoglobin, a naturally occurring hemoglobin-binding protein, fully protects against lethality. Therefore, haptoglobin may not only accelerate the clearance of free hemoglobin, but also limit its utilization by adventitious bacteria. Haptoglobin may have therapeutic potential in the treatment of life-threatening, hemoglobin-driven bacterial infections.
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Citations
Cited by
Application of acute phase protein measurements in veterinary clinical chemistry
Petersen, H. H., Nielsen, J. P., & Heegaard, P. M. H. (2004) · Veterinary Research · doi:10.1051/vetres:2004002 · Cited by 1,060
Iron, Infections, and Anemia of Inflammation
Jurado, R. L. (1997) · Clinical Infectious Diseases · doi:10.1086/515549 · Cited by 358
The Toxicities of Native and Modified Hemoglobins
Everse, J., & Hsia, N. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00499-6 · Cited by 346
Accelerated autoxidation and heme loss due to instability of sickle hemoglobin.
Hebbel, R. P., Morgan, W. T., Eaton, J. W., & Hedlund, B. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.1.237 · Cited by 306
Self-citationStojiljkovic, I., & Hantke, K. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00465.x · Cited by 205
Metadata
- Authors
- Eaton, J. W., Brandt, P., Mahoney, J. R., & Lee, J. T.
- Venue
- Science
- Published
- 1982-02-05
- Volume
- 215
- Issue
- 4533
- Pages
- 691-693
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964260180
- Cited by
- 295
- References
- 0
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Haptoglobin: A Natural Bacteriostat. https://app.cochat.ai/papers/10.1126/science.7036344
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- Eaton, J. W., Brandt, P., Mahoney, J. R., & Lee, J. T. (1982). Haptoglobin: A Natural Bacteriostat. Science. https://doi.org/10.1126/science.7036344
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
