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Cited by 3,627Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Whitehouse, PJ, Price, DL, Struble, RG, Clark, AW, Coyle, JT, DeLong, Mahlon R.·1982·Science
DOI 10.1126/science.7058341
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Abstract

Recent evidence indicates that the nucleus basalis of Meynert, a distinct population of basal forebrain neurons, is a major source of cholinergic innervation of the cerebral cortex. Postmortem studies have previously demonstrated profound reduction in the presynaptic markers for cholinergic neurons in the cortex of patients with Alzheimer's disease and senile dementia of the Alzheimer's type. The results of this study show that neurons of the nucleus basalis of Meynert undergo a profound (greater than 75 percent) and selective degeneration in these patients and provide a pathological substrate of the cholinergic deficiency in their brains. Demonstration of selective degeneration of such neurons represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and, as such, points to a critical subcortical lesion in Alzheimer's patients.

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Crossref · 10.1126/science.7058341

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44 of 44 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 10

  1. Brody, H., Alzheimer's Disease: Senile Dementia and Related Disorders 7: 345 (1978).
  2. Coyle, J. T., Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders: 149 (1981).
  3. DAVIS, K.L., BRAIN ACETYLCHOLINE: 205 (1979).
  4. DRACHMAN, D.A., AGING 7: 141 (1978).
  5. HASSLER, R, BEHAV AGING NERVOUS: 284 (1965).
  6. KUHAR, M.J., BIOL CHOLINERGIC FUN: 3 (1976).
  7. PARENT, A, ADVANCES IN NEUROLOGY 24: 1 (1979).
  8. TOMLINSON, B.E., DEMENTIA: 113 (1977).
  9. WANG, H, AGING DEMENTIA: 1 (1977).
  10. WANG, H.S., REPORT PANEL INFLAMM: 61 (1979).

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Metadata

Authors
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R.
Affiliations
  • Johns Hopkins University (US)
  • Neuropathology Laboratory, Departments of Pathology and Neurology, Baltimore, Maryland 21205
  • Departments of Pharmacology and Experimental Therapy, Psychiatry, and Neuroscience, Baltimore, Maryland 21205
ORCID
DeLong, Mahlon R.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1982-03-05
Volume
215
Issue
4537
Pages
1237-1239
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7058341
OpenAlex
W2093374391
Semantic Scholar
e0380e88fdffd5a546eb76a1d2eb7d05db143f94
Cited by
3,627
References
44
Citations by year
2026: 52 · 2025: 42 · 2024: 53 · 2023: 67 · 2022: 62 · 2021: 91 · 2020: 95 · 2019: 66 · 2018: 63 · 2017: 66 · 2016: 82 · 2015: 65 · 2014: 73 · 2013: 63 · 2012: 56
FWCI
110.00
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Alzheimer's disease, senile dementia, nucleus basalis of Meynert, basal forebrain, cholinergic neurons, neuronal loss, cholinergic deficit, cerebral cortex, presynaptic markers, subcortical lesions
MeSH terms
Acetylcholine, Alzheimer Disease, Basal Ganglia, Dementia, Humans, Neural Pathways

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