Cited by 801Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Some morphometric aspects of the brain in senile dementia of the alzheimer type

Terry, Robert D., Peck, Arthur, DeTeresa, Richard, Schechter, Ruben, Horoupian, Dikran S.·1981·Annals of Neurology

Abstract

Image analysis apparatus was used to count and measure glial and neuronal perikarya in ten size classes in the midfrontal region and superior temporal gyrus of 18 patients with senile dementia of the Alzheimer type for comparison with 12 age-matched normal specimens. Brain weight was about 8% less in the dementia group. The major differences had to do with larger neurons, which in dementia were reduced by about 40% in the frontal cortex and 46% in the temporal region. The concentration of neuritic plaques did not correlate significantly with brain weight, cortical thickness, or cell counts.

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Crossref · 10.1002/ana.410100209

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Authors
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Terry, Robert D.
Venue
Annals of Neurology
Publisher
Wiley
Published
1981-08
Volume
10
Issue
2
Pages
184-192
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2162298355
Cited by
801
References
1
Citations by year
2025: 3 · 2024: 9 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 2 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 11
FWCI
20.03
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, senile dementia, brain morphometry, neuronal perikarya, glial cells, brain weight, cortical thickness, neuritic plaques, frontal cortex, superior temporal gyrus
MeSH terms
Aged, Alzheimer Disease, Cell Count, Dementia, Female, Frontal Lobe, Humans, Male, Neuroglia, Neurons, Organ Size, Temporal Lobe

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