The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Loss of Division Potential in Vitro: Aging or Differentiation?: Departure of cells from cycle may not be a sign of aging, but a sign of differentiation.
Abstract
We have examined the hypothesis that diploid cells grown in vitro age, and propose that only proliferative potential and not life-span is telescoped. We suggest that explanted or transplanted diploid cells are driven to divide by the process of subculturing in vitro or in vivo and, in response to this pressure, also complete their differentiation and become refractory to further mitotic stimulation. We conclude that differentiation rather than "mortality" distinguishes diploid from transformed cells and that the former may not age in vitro, but are lost because culture methods are selective for cycling cells.
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Citations
Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Morphologic changes accompanying senescence of cultured human diploid cells
Robbins, E., Levine, E. M., & Eagle, H. (1970) · The Journal of Experimental Medicine · doi:10.1084/jem.131.6.1211 · Cited by 247
Cited by
Replicative Senescence: the Human Fibroblast Comes of Age
Goldstein, S. (1990) · Science · doi:10.1126/science.2204114 · Cited by 653
Lifestyle-related factors and environmental agents causing cancer: An overview
Irigaray, P., Newby, J. A., Clapp, R., Hardell, L., Howard, V., Montagnier, L., Epstein, S., & Belpomme, D. (2007) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2007.10.006 · Cited by 368
Smith, J. R., & Whitney, R. G. (1980) · Science · doi:10.1126/science.7350644 · Cited by 289
Mine, S., Fortunel, N. O., Pageon, H., & Asselineau, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004066 · Cited by 255
Blocking negative effects of senescence in human skin fibroblasts with a plant extract
Lämmermann, I., Terlecki-Zaniewicz, L., Weinmüllner, R., Schosserer, M., Dellago, H., de Matos Branco, A. D., Autheried, D., Sevcnikar, B., Kleissl, L., Berlin, I., et al. (2018) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-018-0023-5 · Cited by 84
Metadata
- Authors
- Bell, E., Marek, L. F., Levinstone, D. S., Merrill, C., Sher, S., Young, I. T., & Eden, M.
- Venue
- Science
- Published
- 1978-12-15
- Volume
- 202
- Issue
- 4373
- Pages
- 1158-1163
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3207591370
- Cited by
- 190
- References
- 2
- FWCI
- 20.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Loss of Division Potential in Vitro: Aging or Differentiation?: Departure of cells from cycle may not be a sign of aging, but a sign of differentiation. https://app.cochat.ai/papers/10.1126/science.725592
- The paper
- Bell, E., Marek, L. F., Levinstone, D. S., Merrill, C., Sher, S., Young, I. T., & Eden, M. (1978). Loss of Division Potential in Vitro: Aging or Differentiation?: Departure of cells from cycle may not be a sign of aging, but a sign of differentiation. Science. https://doi.org/10.1126/science.725592
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
