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Altering Genotype and Phenotype by DNA-Mediated Gene Transfer
Abstract
Transformation, or DNA-mediated gene transfer, permits the introduction of new genetic information into a cell and frequently results in a change in phenotype. The transforming DNA is ultimately integrated into a recipient cell chromosome. No unique chromosomal locations are apparent; different lines contain the transforming DNA on different chromosomes. Expression of transformed genes frequently results in the synthesis of new polypeptide products which restore appropriate mutant cells to the wild-type phenotype. Thus transformation provides an in vivo assay for the functional role of DNA sequence organization about specific genes. Transforming genes coding for selectable functions, such as adenine phosphoribosyltransferase or thymidine kinase, have now been isolated by utilizing transformation in concert with molecular cloning. Finally, transformation may provide a general approach to the analysis of complex heritable phenotypes by permitting the distinction between phenotypic changes without concomitant changes in DNA and functional genetic rearrangements.
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Citations
Cited by
Genetic Transformation of Drosophila with Transposable Element Vectors
Rubin, G. M., & Spradling, A. C. (1982) · Science · doi:10.1126/science.6289436 · Cited by 3,014
DNA Methylation and Gene Function
Razin, A., & Riggs, A. D. (1980) · Science · doi:10.1126/science.6254144 · Cited by 2,071
Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
Banerji, J., Rusconi, S., & Schaffner, W. (1981) · Cell · doi:10.1016/0092-8674(81)90413-x · Cited by 1,724
Mulligan, R. C., & Berg, P. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.4.2072 · Cited by 982
Promoter Sequences of Eukaryotic Protein-Coding Genes
Corden, J., Wasylyk, B., Buchwalder, A., Sassone-Corsi, P., Kedinger, C., & Chambon, P. (1980) · Science · doi:10.1126/science.6251548 · Cited by 952
Metadata
- Authors
- Pellicer, A., Robins, D., Wold, B., Sweet, R., Jackson, J., Lowy, I., Roberts, J. M., Sim, G. K., Silverstein, S., & Axel, R.
- Venue
- Science
- Published
- 1980-09-19
- Volume
- 209
- Issue
- 4463
- Pages
- 1414-1422
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033819427
- Cited by
- 231
- References
- 0
- FWCI
- 33.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pellicer, A., Robins, D., Wold, B., Sweet, R., Jackson, J., Lowy, I., Roberts, J. M., Sim, G. K., Silverstein, S., & Axel, R. (1980). Altering Genotype and Phenotype by DNA-Mediated Gene Transfer. Science. https://doi.org/10.1126/science.7414320
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