The Fas Death Factor

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736

Social controls on cell survival and cell death

RAFF, M. C. (1992) · Nature · doi:10.1038/356397a0 · Cited by 2,591

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

Suda, T., Takahashi, T., Golstein, P., & Nagata, S. (1993) · Cell · doi:10.1016/0092-8674(93)90326-l · Cited by 2,494

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Jonjić, S., Mutter, W., Weiland, F., Reddehase, M. J., & Koszinowski, U. H. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1199 · Cited by 2,106

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

Smith, C. A., Farrah, T., & Goodwin, R. G. (1994) · Cell · doi:10.1016/0092-8674(94)90372-7 · Cited by 1,909

Lethal effect of the anti-Fas antibody in mice

Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

Dhein, J., Walczak, H., Bäumler, C., Debatin, K., & Krammer, P. (1995) · Nature · doi:10.1038/373438a0 · Cited by 1,814

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

Kägi, D., Ledermann, B., Bürki, K., Seiler, P. J., Odermatt, B., Olsen, K. J., Podack, E. R., Zinkernagel, R. M., & Hengartner, H. (1994) · Nature · doi:10.1038/369031a0 · Cited by 1,758

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Mӧller, P., Falk, W., Debatin, K., & Krammer, P. H. (1989) · Science · doi:10.1126/science.2787530 · Cited by 1,716

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

Andrews, B. S., Eisenberg, R. A., Theofilopoulos, A. N., Izui, S., Wilson, C. B., McConahey, P. J., Murphy, E. D., Roths, J. B., & Dixon, F. J. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.148.5.1198 · Cited by 1,600

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

Kägi, D., Vignaux, F., Ledermann, B., Bürki, K., Depraetere, V., Nagata, S., Hengartner, H., & Golstein, P. (1994) · Science · doi:10.1126/science.7518614 · Cited by 1,544

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., & Nagata, S. (1994) · Cell · doi:10.1016/0092-8674(94)90375-1 · Cited by 1,526

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

RAFF, M. C., Barres, B. A., Burne, J. F., Coles, H., Ishizaki, Y., & Jacobson, M. D. (1993) · Science · doi:10.1126/science.8235590 · Cited by 1,450

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

Yonehara, S., Ishii, A., & Yonehara, M. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1747 · Cited by 1,398

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

Miura, M. (1993) · Cell · doi:10.1016/0092-8674(93)90486-a · Cited by 1,382

A novel domain within the 55 kd TNF receptor signals cell death

Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

Cohen, P. L., & Eisenberg, R. A. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001331 · Cited by 1,169

Apoptosis And Programmed Cell Death In Immunity

Cohen, J., Duke, R. C., Fadok, V. A., & Sellins, K. S. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.001411 · Cited by 1,112

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

Cheng, J., Zhou, T., Liu, C., Shapiro, J. P., Brauer, M. J., Kiefer, M. C., Barr, P. J., & Mountz, J. D. (1994) · Science · doi:10.1126/science.7510905 · Cited by 1,108

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

Lowin, B., Hahne, M., Mattmann, C., & Tschopp, J. (1994) · Nature · doi:10.1038/370650a0 · Cited by 1,059

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

Rothe, M., Wong, S. C., Henzel, W. J., & Goeddel, D. V. (1994) · Cell · doi:10.1016/0092-8674(94)90532-0 · Cited by 1,054

Fas ligand mediates activation-induced cell death in human T lymphocytes.

Alderson, M. R., Tough, T. W., Davis-Smyth, T., Braddy, S., Falk, B. A., Schooley, K., Goodwin, R. G., Smith, C. A., Ramsdell, F., & Lynch, D. H. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.71 · Cited by 933

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

Kolesnick, R. N. (1994) · Cell · doi:10.1016/0092-8674(94)90147-3 · Cited by 916

Fas and Fas ligand: lpr and gld mutations

Nagata, S., & Suda, T. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80069-7 · Cited by 889

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

Webb, S. R., Morris, C., & Sprent, J. (1990) · Cell · doi:10.1016/0092-8674(90)90420-j · Cited by 885

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Milian, J. A., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90410-7 · Cited by 857

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

Itoh, N., & Nagata, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82075-0 · Cited by 845

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

Oehm, A., Behrmann, I., Falk, W., Pawlita, M., Maier, G., Klas, C., Li-Weber, M., Richards, S., Dhein, J., & Trauth, B. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50076-x · Cited by 834

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen

Watanabe‐Fukunaga, R., Brannan, C. I., Itoh, N., Yonehara, S., Copeland, N. G., Jenkins, N. A., & Nagata, S. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.4.1274 · Cited by 815

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H., & Ley, T. J. (1994) · Cell · doi:10.1016/0092-8674(94)90376-x · Cited by 815

Checkpoints of dueling dimers foil death wishes

Oltvai, Z. N. (1994) · Cell · doi:10.1016/0092-8674(94)90188-0 · Cited by 795

Negative selection of lymphocytes

Nossal, G. J. V. (1994) · Cell · doi:10.1016/0092-8674(94)90331-x · Cited by 794

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

Rouvier, É., Luciani, M., & Golstein, P. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.1.195 · Cited by 783

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

Wiegmann, K., Schütze, S., Machleidt, T., Witte, D., & Krönke, M. (1994) · Cell · doi:10.1016/0092-8674(94)90275-5 · Cited by 714

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

Singer, G. G., & Abbas, A. K. (1994) · Immunity · doi:10.1016/1074-7613(94)90067-1 · Cited by 689

Peripheral Selection of the T Cell Repertoire

Rocha, B., & von Boehmer, H. (1991) · Science · doi:10.1126/science.1900951 · Cited by 656

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

Tanaka, M., Suda, T., Takahashi, T., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07096.x · Cited by 641

Mechanism of Lymphocyte-Mediated Cytotoxicity

Henkart, P. A. (1985) · Annual Review of Immunology · doi:10.1146/annurev.immunol.3.1.31 · Cited by 602

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

Newmeyer, D. (1994) · Cell · doi:10.1016/0092-8674(94)90203-8 · Cited by 581

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

Cifone, M. G., Maria, R. D., Roncaioli, P., Rippo, M. R., Azuma, M., Lanier, L. L., Santoni, A., & Testi, R. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.4.1547 · Cited by 573

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

Scollay, R. G., Butcher, E. C., & Weissman, I. L. (1980) · European Journal of Immunology · doi:10.1002/eji.1830100310 · Cited by 555

Positive selection of lymphocytes

von Boehmer, H. (1994) · Cell · doi:10.1016/0092-8674(94)90330-1 · Cited by 548

Programmed cell death and Bcl‐2 protection in the absence of a nucleus.

Jacobson, M. D., Burne, J. F., & RAFF, M. C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06459.x · Cited by 548

Patterns of cell death.

Walker, N. I., HARMON, B. V., Gobe, G. C., & Kerr, J. F. R. (1988) · PubMed · Cited by 527

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

Adachi, M., Watanabe‐Fukunaga, R., & Nagata, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1756 · Cited by 509

Purification and characterization of the Fas-ligand that induces apoptosis.

Suda, T., & Nagata, S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.3.873 · Cited by 506

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood

Miyawaki, T., Uehara, T., Nibu, R., Tsuji, T., Yachie, A., Yonehara, S., & Taniguchi, N. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.11.3753 · Cited by 494

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.

Ando, K., Moriyama, T., Guidotti, L. G., Wirth, S., Schreiber, R. D., Schlicht, H. J., Huang, S. N., & Chisari, F. V. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.5.1541 · Cited by 449

Activation interferes with the APO-1 pathway in mature human T cells

Klas, C., Debatin, K., Jonker, R. R., & Krammer, P. H. (1993) · International Immunology · doi:10.1093/intimm/5.6.625 · Cited by 447

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

Jarvis, W. D., Kolesnick, R., Fornari, F. A., Traylor, R. S., Gewirtz, D. A., & Grant, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.73 · Cited by 447

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

Lazebnik, Y. A., Cole, S., Cooke, C. A., Nelson, W. G., & Earnshaw, W. C. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.1.7 · Cited by 445

Effect of bcl-2 on Fas antigen-mediated cell death.

Itoh, N., Tsujimoto, Y., & Nagata, S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.2.621 · Cited by 434

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

Weinberg, J. B., Granger, D. L., Pisetsky, D. S., Seldin, M. F., Misukonis, M. A., Mason, S. N., Pippen, A. M., Ruiz, P., Wood, E. R., & Gilkeson, G. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.651 · Cited by 434

Human Fas ligand: gene structure, chromosomal location and species specificity

Takahashi, T., Tanaka, M., Inazawa, J., Abe, T., Suda, T., & Nagata, S. (1994) · International Immunology · doi:10.1093/intimm/6.10.1567 · Cited by 433

Cell nucleus and DNA fragmentation are not required for apoptosis.

Schulze‐Osthoff, K., Walczak, H., Dröge, W., & Krammer, P. H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.1.15 · Cited by 428

Unraveling Function in the TNF Ligand and Receptor Families

Beutler, B., & Huffel, C. V. (1994) · Science · doi:10.1126/science.8171316 · Cited by 419

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

Podack, E. R., Young, J. D., & Cohn, Z. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8629 · Cited by 400

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

Russell, J. H., Rush, B., Weaver, C. T., & Wang, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4409 · Cited by 398

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

Izui, S., Kelley, V. E., Masuda, K., Yoshida, H., Roths, J. B., & Murphy, E. D. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.1.227 · Cited by 386

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

Stalder, T., Hahn, S., & Erb, P. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.3.1127 · Cited by 379

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

Owen‐Schaub, L. B., Yonehara, S., Crump, W. L., & Grimm, E. A. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90187-t · Cited by 372

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

Shi, L., Kraut, R. P., Aebersold, R. H., & Greenberg, A. H. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.2.553 · Cited by 367

Diversity of Cytokine Synthesis and Function of Mouse CD4+ T Cells

Mosmann, T. R., Schumacher, J. H., Street, N. F., Budd, R. C., O’Garra, A., Fong, T. A. T., Bind, M. W., Moore, K. W., Sher, A., & Fiorentino, D. F. (1991) · Immunological Reviews · doi:10.1111/j.1600-065x.1991.tb00612.x · Cited by 362

Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C

Hiramatsu, N., Hayashi, N., Katayama, K., Mochizuki, K., Kawanishi, Y., Kasahara, A., Fusamoto, H., & Kamada, T. (1994) · Hepatology · doi:10.1002/hep.1840190606 · Cited by 355

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

Hu, H., O’Rourke, K. M., Boguski, M. S., & Dixit, V. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43772-6 · Cited by 341

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

Watson, M., Rao, J. K., Gilkeson, G. S., Ruiz, P., Eicher, E. M., Pisetsky, D. S., Matsuzawa, A., Rochelle, J. M., & Seldin, M. F. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1645 · Cited by 338

Fas and Fas Ligand: A Death Factor and Its Receptor

Nagata, S. (1994) · Advances in immunology · doi:10.1016/s0065-2776(08)60672-0 · Cited by 335

Kinetics of mature T-cell development in the thymus.

Egerton, M., Scollay, R. G., & Shortman, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2579 · Cited by 333

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

Lynch, D. H., Watson, M. L., Alderson, M. R., Baum, P. R., Miller, R. E., Tough, T. W., Gibson, M., Davis-Smyth, T., Smiths, C. A., Hunter, K. W., et al. (1994) · Immunity · doi:10.1016/1074-7613(94)90106-6 · Cited by 331

Clonal expansion precedes anergy and death of Vβ8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo

MacDonald, H. R., Baschieri, S., & Lees, R. K. (1991) · European Journal of Immunology · doi:10.1002/eji.1830210827 · Cited by 320

Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes

Kabelitz, D., Pohl, T., & Pechhold, K. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90231-9 · Cited by 311

Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death

Ramsdell, F., Seaman, M. S., Miller, R. E., Picha, K. S., Kennedy, M. K., & Lynch, D. H. (1994) · International Immunology · doi:10.1093/intimm/6.10.1545 · Cited by 311

Divergent signalling via APO‐1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

Schulze‐Osthoff, K., Krammer, P., & Dröge, W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06780.x · Cited by 302

A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.

Roths, J. B., Murphy, E. D., & Eicher, E. M. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.159.1.1 · Cited by 301

A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease.

Sneller, M. C., Straus, S. E., Jaffe, E. S., Jaffe, J. S., Fleisher, T. A., Stetler‐Stevenson, M., & Strober, W. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115867 · Cited by 300

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

Ju, S., Cui, H., Panka, D. J., Ettinger, R., & Marshak‐Rothstein, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4185 · Cited by 293

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

Wu, J., Zhou, T., He, J. H., & Mountz, J. D. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.461 · Cited by 287

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

Kojima, H., Shinohara, N., Hanaoka, S., Shirota-Someya, Y., Takagaki, Y., Ohno, H., Saito, T., Katayama, T., Yagita∥, H., Okumura, K., et al. (1994) · Immunity · doi:10.1016/1074-7613(94)90066-3 · Cited by 286

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV‐1‐regulated protein gp34.

Baum, P. R., Gayle, R. B., Ramsdell, F., Srinivasan, S., Sorensen, R. A., Watson, M., Seldin, M. F., Baker, E. G., Sutherland, G. R., & Clifford, K. N. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06715.x · Cited by 283

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

Hanabuchi, S., Koyanagi, M., Kawasaki, A., Shinohara, N., Matsuzawa, A., Nishimura, Y., Kobayashi, Y., Yonehara, S., Yagita∥, H., & Okumura, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4930 · Cited by 281

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens

Dhein, J., Daniel, P. T., Trauth, B. C., Oehm, A., Möller, P., & Krammer, P. H. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.10.3166 · Cited by 278

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

Chu, J. L., Drappa, J., Parnassa, A. P., & Elkon, K. B. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.723 · Cited by 245

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

Shiver, J. W., Su, L., & Henkart, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90359-k · Cited by 235

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen

McCormack, J. E., Callahan, J. E., Kappler, J. W., & Marrack, P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.9.3785 · Cited by 234

Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor- alpha secretion

Oyaizu, N., McCloskey, T. W., Than, S., Hu, R., Kalyanaraman, V. S., & Pahwa, S. G. (1994) · Blood · doi:10.1182/blood.v84.8.2622.2622 · Cited by 207

Fas-Mediated Apoptosis in Primary Cultured Mouse Hepatocytes

Ni, R., Tomita, Y., Matsuda, K., Ichihara, A., Ishimura, K., Ogasawara, J., & Nagata, S. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1349 · Cited by 198

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

Wong, G. H., & Goeddel, D. V. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1751 · Cited by 196

T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

Anel, A., Buferne, M., Boyer, C., Schmitt‐Verhulst, A., & Golstein, P. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241032 · Cited by 196

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

Ogasawara, J., Suda, T., & Nagata, S. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.485 · Cited by 194

Cytotoxic T lymphocyte mediated lysis without release of serine esterase

Ostergaard, H. L., Kane, K. P., Mescher, M. F., & Clark, W. R. (1987) · Nature · doi:10.1038/330071a0 · Cited by 191

TCR/CD3 coupling to Fas-based cytotoxicity.

Vignaux, F., Vivier, É., MALISSEN, B., Depraetere, V., Nagata, S., & Golstein, P. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.781 · Cited by 184

The molecular mechanism of lymphocyte-mediated tumor cell lysis

Podack, E. R. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90164-1 · Cited by 180

Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.

Eischen, C. M., Dick, C. J., & Leibson, P. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.5.1947 · Cited by 179

Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.

Daniel, P. T., & Krammer, P. H. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.12.5624 · Cited by 176

Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

Trenn, G., Takayama, H., & Sitkovsky, M. V. (1987) · Nature · doi:10.1038/330072a0 · Cited by 171

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]

Debatin, K., Fahrig-Faissner, A., Enenkel-Stoodt, S., Kreuz, W., Benner, A., & Krammer, P. (1994) · Blood · doi:10.1182/blood.v83.10.3101a.3101a · Cited by 169

Structure of the human APO‐1 gene

Behrmann, I., Walczak, H., & Krammer, P. H. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241221 · Cited by 165

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

Rathmell, J. C., & Goodnow, C. C. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2831 · Cited by 155

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

Vignaux, F., & Golstein, P. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240421 · Cited by 151

Selection of the T cell receptor repertoire in Lpr mice.

Herron, L. R., Eisenberg, R. A., Roper, E., Kakkanaiah, V. N., Cohen, P. L., & Kotzin, B. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.7.3450 · Cited by 149

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

Russell, J. H., & Wang, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230951 · Cited by 147

Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia

Debatin, K., Krammer, P. H., Goldman, C. K., Bamford, R. N., & Waldmann, T. A. (1990) · The Lancet · doi:10.1016/0140-6736(90)90735-n · Cited by 140

Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions.

Clement, M., & Stamenkovic, I. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.2.557 · Cited by 140

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

Wu, J., Zhou, T., Zhang, J., He, J., Gause, W. C., & Mountz, J. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2344 · Cited by 140

gld/gld mice are unable to express a functional ligand for Fas

Ramsdell, F., Seaman, M. S., Miller, R. E., Tough, T. W., Alderson, M. R., & Lynch, D. H. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240422 · Cited by 139

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

Sidman, C. L., Marshall, J. D., & von Boehmer, H. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220231 · Cited by 130

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.

Allen, R. D., Marshall, J. D., Roths, J. B., & Sidman, C. L. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.5.1367 · Cited by 129

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.

Matsuzawa, A., Moriyama, T., Kaneko, T., Tanaka, M., Kimura, M., Ikeda, H., & Katagiri, T. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.2.519 · Cited by 128

Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome.

Chu, J. L., Ramos, P. S., Rosendorff, A., Nikolić‐Žugić, J., Lacy, E., Matsuzawa, A., & Elkon, K. B. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.393 · Cited by 122

Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication.

Kobayashi, N., Hamamoto, Y., Yamamoto, N., Ishii, A., Yonehara, M., & Yonehara, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9620 · Cited by 118

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.

Watanabe, D., Suda, T., Hashimoto, H., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb06970.x · Cited by 114

Fatal interactions: fas-induced apoptosis of mature T cells

Crispe, I. N. (1994) · Immunity · doi:10.1016/1074-7613(94)90064-7 · Cited by 110

Association of lpr gene with graft-vs.-host disease-like syndrome.

Theofilopoulos, A. N., BALDERAS, R. S., Gozes, Y., Aguado, M. T., Hang, L. M., Morrow, P. R., & Dixon, F. J. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.1.1 · Cited by 108

No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis

Hug, H., Enari, M., & Nagata, S. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00852-3 · Cited by 107

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

Moller, P., Henne, C., Leithäuser, F., Eichelmann, A., Schmidt, A., Brüderlein, S., Dhein, J., & Krammer, P. (1993) · Blood · doi:10.1182/blood.v81.8.2067.2067 · Cited by 98

Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype

Falk, M., Trauth, B. C., Debatin, K., Klas, C., Gregory, C., Rickinson, A. B., Calender, A., Lenoir, G., Ellwart, J., & Krammer, P. (1992) · Blood · doi:10.1182/blood.v79.12.3300.bloodjournal79123300 · Cited by 96

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

Wang, Z., Dudhane, A., Orlikowsky, T. W., Clarke, K., Li, X., Darżynkiewicz, Z., & Hoffmann, M. K. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240714 · Cited by 93

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity.

Nakajima, H., Golstein, P., & Henkart, P. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.5.1905 · Cited by 90

Assignment of the human fas antigen gene (FAS) to 10q24.1

Inazawa, J., Itoh, N., Abe, T., & Nagata, S. (1992) · Genomics · doi:10.1016/s0888-7543(05)80200-9 · Cited by 86

The role of the Fas lytic pathway in a perforin-less CTL hybridoma.

Walsh, C. M., Glass, A. A., Chiu, V. K., & Clark, W. R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2506 · Cited by 84

Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice.

Lowrance, J. H., O’Sullivan, F. X., Caver, T. E., Waegell, W., & Gresham, H. D. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1693 · Cited by 83

A linkage map of mouse Chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation

Watson, M. L., D’Eustachio, P., Mock, B. A., Steinberg, A. D., Morse, H. C., Oakey, R. J., Howard, T. A., Rochelle, J. M., & Seldin, M. F. (1992) · Mammalian Genome · doi:10.1007/bf00302874 · Cited by 83

A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice

Gillette‐Ferguson, I., & Sidman, C. L. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240526 · Cited by 80

Transcriptional Repression and Differential Splicing of Fas m-RNA by Early Transposon (ETn) Insertion in Autoimmune LPR Mice

Kobayashi, S., Hirano, T., Kakinuma, M., & Uede, T. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1262 · Cited by 77

Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin).

Young, J. D., Damiano, A., Dinome, M. A., Leong, L. G., & Cohn, Z. A. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.5.1371 · Cited by 71

T-lymphocyte-mediated cytolysis as an excitatory process of the target

Tirosh, R., & Berke, G. (1985) · Cellular Immunology · doi:10.1016/0008-8749(85)90300-4 · Cited by 70

A molecular genetic linkage map of mouse chromosome 19, including thelpr, Ly-44, andTdt genes

Watanabe, T., Sakai, Y., Miyawaki, S., Shimizu, A., Koiwai, O., & Ohno, K. (1991) · Biochemical Genetics · doi:10.1007/bf00554140 · Cited by 66

APOPTOSIS AND THE IMMUNE RESPONSE

Gregory, C. D. (1996) · Shock · doi:10.1097/00024382-199602000-00013 · Cited by 65

A calcium- and perforin-independent pathway of killing mediated by murine cytolytic lymphocytes.

Young, J. D., Clark, W. R., Liu, C. C., & Cohn, Z. A. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.6.1894 · Cited by 62

Early and late B-cell development in the mouse

Rajewsky, K. (1992) · Current Opinion in Immunology · doi:10.1016/0952-7915(92)90008-3 · Cited by 53

Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo.

Webb, S. R., Hutchinson, J., Hayden, K., & Sprent, J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.2.586 · Cited by 52

The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19

Lichter, P., Walczak, H., Weitz, S., Behrmann, I., & Krammer, P. H. (1992) · Genomics · doi:10.1016/s0888-7543(05)80302-7 · Cited by 48

The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes

Andjelić, S., Drappa, J., Lacy, E., Elkon, K. B., & Nikoiić-Žugić, J. (1994) · International Immunology · doi:10.1093/intimm/6.1.73 · Cited by 42

In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR- beta low cells.

Laouar, Y., & Ezine, S. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.9.3948 · Cited by 35

Limited specific T-cell mediated cytolysis in the absence of extracellular Ca2+.

Maclennan, I. C. M., Gotch, F., & Golstein, P. (1980) · PubMed · Cited by 35

The expansion of a CD4+ T cell population bearing a distinctive β chain in MRL lpr/lpr mice suggests a role for the fas protein in peripheral T cell selection

Musette, P., Pannetier, C., Gachelin, G., & Kourilsky, P. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241128 · Cited by 34

Establishment of apoptosis‐inducing monoclonal antibody 2D1 and 2D1‐resistant variants of human T cell lines

Takahashi, S., Sato, N., Takayama, S., Ichimiya, S., Satoh, M., Hyakumachi, N., & Kikuchi, K. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230831 · Cited by 30

Calcium is essential for both the membrane binding and lytic activity of pore-forming protein (perforin) from cytotoxic T-lymphocyte

Shoichi, I., Kiyoshi, M., Hirotaka, K., Tsukahara, T., Arahata, K., & Sugita, H. (1990) · Molecular Immunology · doi:10.1016/0161-5890(90)90090-m · Cited by 27

Increased Fas antigen expression in murine retrovirus‐induced immunodeficiency syndrome, MAIDS

Hiromatsu, K., Aoki, Y., Makino, M., Matsumoto, Y., Mizuochi, T., Gotoh, Y., Nomoto, K., Ogasawara, J., Nagata, S., & Yoshikai, Y. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241028 · Cited by 27

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

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Apoptosis by Death Factor

Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,934

The TNF and TNF Receptor Superfamilies

Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998) · Nature · doi:10.1038/34112 · Cited by 3,239

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046

Fas ligand：Can it ever be tamed？

Rcduke, & Khance (2002) · Cell Research

Molecular and Cellular Mechanisms RegulatingTand B Cell Apoptosis through Fas/FasL Interaction

Ju, S., Matsui, K., & Özdemirli, M. (1999) · International Reviews of Immunology · doi:10.3109/08830189909088495 · Cited by 59

A death factor--the other side of the coin.

Nagata, S. (1996) · PubMed · Cited by 15

Apoptosis Mediated by the Fas System

Nagata, S. (1996) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-79850-4_6 · Cited by 68

Fas‐induced apoptosis, and diseases caused by its abnormality

Nagata, S. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.d01-214.x · Cited by 58