Jak-STAT Signaling Induced by the v- abl oncogene
Abstract
The effect of the v- abl oncogene of the Abelson murine leukemia virus (A-MuLV) on the Jak-STAT pathway of cytokine signal transduction was investigated. In murine pre-B lymphocytes transformed with A-MuLV, the Janus kinases (Jaks) Jak1 and Jak3 exhibited constitutive tyrosine kinase activity, and the STAT proteins (signal transducers and activators of transcription) normally activated by interleukin-4 and interleukin-7 were tyrosine-phosphorylated in the absence of these cytokines. Coimmunoprecipitation experiments revealed that in these cells v-Abl was physically associated with Jak1 and Jak3. Inactivation of v-Abl tyrosine kinase in a pre-B cell line transformed with a temperature-sensitive mutant of v- abl resulted in abrogation of constitutive Jak-STAT signaling. A direct link may exist between transformation by v- abl and cytokine signal transduction.
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A number of transformed cell lines as well as samples from human cancers are reported to contain constitutively activated STAT3.
“A number of transformed cell lines as well as samples from human cancers are reported to contain constitutively activated STAT3.”
From STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration (2002) · cites this paper as [23]
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STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration
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- Authors
- Danial, N. N., Pernis, A., & Rothman, P. B.
- Affiliations
- Columbia University (US)
- Venue
- Science
- Published
- 1995-09-29
- Volume
- 269
- Issue
- 5232
- Pages
- 1875-1877
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029312116
- Cited by
- 325
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai033540-04)
- National Institute of Allergy and Infectious Diseases (AI 33540-02)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- JAK/STAT signaling, Abelson murine leukemia virus, Janus kinase, JAK1, JAK3, STAT proteins, pre-B cells, IL-4, IL-7, cytokine signaling, oncogenic transformation, temperature-sensitive mutants
- MeSH terms
- Animals, B-Lymphocytes, Base Sequence, Cell Line, Transformed, DNA-Binding Proteins, Interferon-gamma, Milk Proteins, Molecular Sequence Data, Phosphorylation, Protein-Tyrosine Kinases, Temperature, Signal Transduction, Trans-Activators, Interleukin-4, Interleukin-7, Genes, abl, STAT5 Transcription Factor, STAT6 Transcription Factor, Mice, Janus Kinase 1, Janus Kinase 3
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