Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
Open accessAbstract
Signal transducer and activator of transcription (STAT) proteins perform key roles in mediating signaling by cytokines and growth factors, including platelet-derived growth factor (PDGF). In addition, Src family kinases activate STAT signaling and are required for PDGF-induced mitogenesis in normal cells. One STAT family member, Stat3, has been shown to have an essential role in cell transformation by the Src oncoprotein. However, the mechanisms by which STAT-signaling pathways contribute to mitogenesis and transformation are not fully defined. We show here that disruption of Stat3 signaling by using dominant-negative Stat3β protein in NIH 3T3 fibroblasts suppresses c-Myc expression concomitant with inhibition of v-Src-induced transformation. Ectopic expression of c-Myc is able to partially reverse this inhibition, suggesting that c-Myc is a downstream effector of Stat3 signaling in v-Src transformation. Furthermore, c -myc gene knockout fibroblasts are refractory to transformation by v-Src, consistent with a requirement for c-Myc protein in v-Src transformation. In normal NIH 3T3 cells, disruption of Stat3 signaling with dominant-negative Stat3β protein inhibits PDGF-induced mitogenesis in a manner that is reversed by ectopic c-Myc expression. Moreover, inhibition of Src family kinases with the pharmacologic agent, SU6656, blocks Stat3 activation by PDGF. These findings, combined together, delineate the signaling pathway, PDGF → Src → Stat3 → Myc, that is important in normal PDGF-induced mitogenesis and subverted in Src transformation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The STAT3 target gene MYC is a potent promoter of cell growth and is required for Src-mediated cellular transformation via STAT3.
“In addition, the STAT3 target gene MYC, which itself encodes a transcription factor, is also a potent promoter of cell growth and is required for Src-mediated cellular transformation via STAT3.45”
From Critical analysis of the potential for targeting STAT3 in human malignancy (2013) · cites this paper as [45]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979 · see citing works
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932 · see citing works
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790 · see citing works
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,296 · see citing works
Hunter, T. R., & Cooper, J. A. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004341 · Cited by 2,142 · see citing works
Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743 · see citing works
Self-citationCatlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernández-Luna, J. L., Nuñez, G., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80011-4 · Cited by 1,638 · see citing works
Self-citationMolecular themes in oncogenesis
Bishop, J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90636-d · Cited by 1,619 · see citing works
The role of STATs in transcriptional control and their impact on cellular function
Bromberg, J., & Darnell, J. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203476 · Cited by 1,201 · see citing works
Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein
Yu, C.-L., Meyer, D. J., Campbell, G. S., Larner, A. C., Carter-Su, C., Schwartz, J., & Jove, R. (1995) · Science · doi:10.1126/science.7541555 · Cited by 931 · see citing works
Self-citationColler, H. A., Grandori, C., Tamayo, P., Colbert, T., Lander, E. S., Eisenman, R. N., & Golub, T. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3260 · Cited by 823 · see citing works
Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice
Socolovsky, M., Fallon, A. E. J., Wang, S., Brugnara, C., & Lodish, H. F. (1999) · Cell · doi:10.1016/s0092-8674(00)81013-2 · Cited by 695 · see citing works
Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., & Hirano, T. (1996) · Immunity · doi:10.1016/s1074-7613(00)80501-4 · Cited by 652 · see citing works
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
Turkson, J., Bowman, T., Garcia, R., Caldenhoven, E., De Groot, R. P., & Jove, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2545 · Cited by 651 · see citing works
Self-citationStat3 Activation Is Required for Cellular Transformation by v- <i>src</i>
Bromberg, J. F., Horvath, C. M., Besser, D., Lathem, W. W., & Darnell, J. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2553 · Cited by 614 · see citing works
The SIF binding element confers sis/PDGF inducibility onto the c‐fos promoter.
Wagner, B. J., Hayes, T. E., Hoban, C. J., & Cochran, B. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07898.x · Cited by 592 · see citing works
Grandis, J. R., Drenning, S. D., Zeng, Q., Watkins, S. C., Melhem, M. F., Endo, S., Johnson, D. E., Huang, L., He, Y., & Kim, J. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4227 · Cited by 588 · see citing works
SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling
Blake, R. A., Broome, M. A., Liu, X., Wu, J., Gishizky, M. L., Sun, L., & Courtneidge, S. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.9018-9027.2000 · Cited by 580 · see citing works
Self-citationIdentification of CDK4 as a target of c-MYC
Hermeking, H., Rago, C., Schuhmacher, M., Li, Q., Barrett, J. F., Obaya, Á. J., O’Connell, B. C., Mateyak, M. K., Tam, W., Kohlhuber, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050586197 · Cited by 471 · see citing works
Self-citationPhenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.
Mateyak, M. K., Obaya, Á. J., Adachi, S., & Sedivy, J. M. (1997) · PubMed · Cited by 445 · see citing works
Self-citationSynergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis
Shirogane, T., Fukada, T., Müller, J. M. M., Shima, D. T., Hibi, M., & Hirano, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80145-4 · Cited by 427 · see citing works
STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene
Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., & Hirano, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.63 · Cited by 396 · see citing works
Dominant negative MYC blocks transformation by ABL oncogenes
Sawyers, C. L., Callahan, W., & Witte, O. N. (1992) · Cell · doi:10.1016/0092-8674(92)90241-4 · Cited by 395 · see citing works
Function of the c-Myc Oncogenic Transcription Factor
Dang, C. V., Resar, L. M. S., Emison, E. S., Kim, S., Li, Q., Prescott, J. E., Wonsey, D. R., & Zeller, K. I. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4686 · Cited by 377 · see citing works
Caldenhoven, E., van Dijk, T. B., Solari, R., Armstrong, J., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L., & de Groot, R. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13221 · Cited by 373 · see citing works
Garcia, R., Yu, C., Hudnall, A. M., Catlett, R., Nelson, K. L., Smithgall, T. E., Fujita, D. J., Ethier, S. P., & Jove, R. (1997) · PubMed · Cited by 369 · see citing works
Self-citationTwamley, G. M., Pepperkok, R., Ansorge, W., & Courtneidge, S. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7696 · Cited by 333 · see citing works
Self-citationMateyak, M. K., Obaya, Á. J., & Sedivy, J. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4672 · Cited by 331 · see citing works
Self-citationJak-STAT Signaling Induced by the v- <i>abl</i> oncogene
Danial, N. N., Pernis, A., & Rothman, P. B. (1995) · Science · doi:10.1126/science.7569929 · Cited by 325 · see citing works
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.
Silvennoinen, O., Schindler, C., Schlessinger, J., & Levy, D. (1993) · Science · doi:10.1126/science.8378775 · Cited by 319 · see citing works
Niu, G., Heller, R. F., Catlett-Falcone, R., Coppola, D., Jaroszeski, M. J., Dalton, W. S., Jove, R., & Yu, H. (1999) · PubMed · Cited by 313 · see citing works
Self-citationMyc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
Barone, M. V., & Courtneidge, S. A. (1995) · Nature · doi:10.1038/378509a0 · Cited by 312 · see citing works
Self-citationSinibaldi, D., Wharton, W., Turkson, J., Bowman, T. L., Pledger, W. J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203947 · Cited by 289 · see citing works
Self-citationTurkson, J., Bowman, T. L., Adnane, J., Zhang, Y., Djeu, J. Y., Sekharam, M., Frank, D. A., Holzman, L. B., Wu, J., Sebti, S. M., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7519 · Cited by 256 · see citing works
Self-citationGould, K. L., & Hunter, T. R. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3345 · Cited by 247 · see citing works
STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
Fukada, T., Ohtani, T., Yoshida, Y., Shirogane, T., Nishida, K., Nakajima, K., Hibi, M., & Hirano, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6670 · Cited by 247 · see citing works
Roche, S., Koegl, M., Barone, M. V., Roussel, M. F., & Courtneidge, S. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.1102 · Cited by 244 · see citing works
Self-citationc-Src, Receptor Tyrosine Kinases, and Human Cancer
Biscardi, J. S., Tice, D. A., & Parsons, S. J. (1999) · Advances in cancer research · doi:10.1016/s0065-230x(08)60774-5 · Cited by 243 · see citing works
Mysterious liaisons: the relationship between c-Myc and the cell cycle
Obaya, Á. J., Mateyak, M. K., & Sedivy, J. M. (1999) · Oncogene · doi:10.1038/sj.onc.1202749 · Cited by 242 · see citing works
Self-citationSTAT proteins as novel targets for cancer therapy
Catlett-Falcone, R., Dalton, W. S., & Jove, R. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199911000-00010 · Cited by 185 · see citing works
Self-citationDifferential Complementation of Bcr-Abl Point Mutants with c-Myc
Afar, D., Goga, A., McLaughlin, J., Witte, O. N., & Sawyers, C. L. (1994) · Science · doi:10.1126/science.8153630 · Cited by 183 · see citing works
Kraker, A. J., Hartl, B. G., Amar, A. M., Barvian, M. R., Showalter, H. D., & Moore, C. W. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00405-6 · Cited by 140 · see citing works
Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G 1
Wu, C., Classon, M., Dyson, N. J., & Harlow, E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3698 · Cited by 139 · see citing works
Broome, M. A., & Hunter, T. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16798 · Cited by 136 · see citing works
Self-citationBesser, D., Bromberg, J., Darnell, J. E., Jr., & Hanafusa, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1401 · Cited by 123 · see citing works
Wang, Y.-Z., Wharton, W., Garcia, R., Kraker, A. J., Jove, R., & Pledger, W. J. (2000) · Oncogene · doi:10.1038/sj.onc.1203548 · Cited by 111 · see citing works
Self-citationHunter, T. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.54.1.897 · Cited by 109 · see citing works
Regulation of both apoptosis and cell survival by the v-Src oncoprotein
Johnson, D., Agochiya, M., Samejima, K., Earnshaw, W. C., Frame, M. C., & Wyke, J. A. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400700 · Cited by 78 · see citing works
Sachsenmaier, C., Sadowski, H. B., & Cooper, J. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202694 · Cited by 66 · see citing works
Aziz, N. A., Cherwinski, H. M., & McMahon, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1101 · Cited by 55 · see citing works
v-Src Generates a p53-Independent Apoptotic Signal
Webb, B. L., Jimenez, E., & Martin, G. S. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9271-9280.2000 · Cited by 52 · see citing works
Broome, M. A., & Courtneidge, S. A. (2000) · Oncogene · doi:10.1038/sj.onc.1203608 · Cited by 45 · see citing works
Self-citationGould, K. L., & Hunter, T. R. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3345-3356.1988 · Cited by 44 · see citing works
Bazarov, A., Adachi, S., Li, S. F., Mateyak, M. K., Wei, S., & Sedivy, J. M. (2001) · PubMed · Cited by 42 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- [8]Garcia R, Yu C L, Hudnall A, Catlett R, Nelson K L, Smithgall T, Fujita D J, Ethier S P, Jove R. Cell Growth Differ. 1997;8:1267–1276. [PubMed] [Google Scholar]
- [34]Mateyak M K, Obaya A J, Adachi S, Sedivy J M. Cell Growth Differ. 1997;8:1039–1048. [PubMed] [Google Scholar]
- [37]Niu G, Heller R, Catlett-Falcone R, Coppola D, Jaroszeski M, Dalton W, Jove R, Yu H. Cancer Res. 1999;59:5059–5063. [PubMed] [Google Scholar]
- [43]Bazarov A V, Adachi S, Li S F, Mateyak M K, Wei S, Sedivy J M. Cancer Res. 2001;61:1178–1186. [PubMed] [Google Scholar]
Cited by
Sorted by citations
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383 · see citing works
Self-citationThe STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278 · see citing works
Self-citationCrosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
Yu, H., Kortylewski, M., & Pardoll, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1995 · Cited by 1,809 · see citing works
Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,375 · see citing works
c-MYC: more than just a matter of life and death
Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Nature reviews. Cancer · doi:10.1038/nrc904 · Cited by 1,172 · see citing works
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
Wang, T., Niu, G., Kortylewski, M., Burdelya, L. G., Shain, K. H., Zhang, S., Bhattacharya, R., Gabrilovich, D. I., Heller, R. F., Coppola, D., et al. (2003) · Nature Medicine · doi:10.1038/nm976 · Cited by 1,159 · see citing works
Self-citationTGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
Hao, Y., Baker, D. A., & ten Dijke, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112767 · Cited by 1,155 · see citing works
Yeatman, T. J. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1366 · Cited by 1,113 · see citing works
Self-citationBuettner, R., Mora, L. B., & Jove, R. (2002) · PubMed · Cited by 1,021 · see citing works
Self-citationConstitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
Niu, G., Wright, K. L., Huang, M., Song, L., Haura, E., Turkson, J., Zhang, S., Wang, T., Sinibaldi, D., Coppola, D., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205260 · Cited by 1,207 · see citing works
Self-citationNF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer
Fan, Y., Mao, R., & Yang, J. (2013) · Protein & Cell · doi:10.1007/s13238-013-2084-3 · Cited by 779 · see citing works
Bromberg, J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15617 · Cited by 846 · see citing works
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
Cartwright, P., McLean, C. A., Sheppard, A. M., Rivett, D., Jones, K., & Dalton, S. (2005) · Development · doi:10.1242/dev.01670 · Cited by 758 · see citing works
Yang, X., Lin, Y., Shi, Y., Li, B., Liu, W., Yin, W., Dang, Y., Chu, Y., Fan, J., & He, R. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2973 · Cited by 748 · see citing works
Mechanisms of Immune Evasion by Tumors
Drake, C. G., Jaffee, E. M., & Pardoll, D. M. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)90002-9 · Cited by 690 · see citing works
Src in cancer: deregulation and consequences for cell behaviour
Frame, M. C. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00040-9 · Cited by 682 · see citing works
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Bai, L., Zhou, H., Xu, R., Zhao, Y., Chinnaswamy, K., McEachern, D., Chen, J., Yang, C.-Y., Liu, Z., Wang, M., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.10.002 · Cited by 652 · see citing works
The molecular targets and therapeutic uses of curcumin in health and disease
Aggarwal, B., Surh, Y., & Shishodia, S. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-46401-5 · Cited by 505 · see citing works
Lo, H., Hsu, S.-C., Xia, W., Cao, X., Shih, J., Wei, Y., Abbruzzese, J. L., Hortobágyi, G. N., & Hung, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0575 · Cited by 625 · see citing works
STAT proteins: From normal control of cellular events to tumorigenesis
Calò, V., Migliavacca, M., Bazan, V., Macaluso, M., Buscemi, M., Gebbia, N., & Russo, A. D. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10364 · Cited by 606 · see citing works
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
Lo, H., Hsu, S.-C., Ali‐Seyed, M., Gündüz, M., Xia, W., Wei, Y., Bartholomeusz, G. A., Shih, J. Y., & Hung, M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.007 · Cited by 539 · see citing works
Mora, L. B., Buettner, R., Seigne, J. D., Diaz, J. I., Ahmad, N., Garcia, R., Bowman, T. L., Falcone, R., Fairclough, R., Cantor, A. B., et al. (2002) · PubMed · Cited by 532 · see citing works
Self-citationThe JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
Hedvat, M., Huszar, D., Herrmann, A., Gozgit, J. M., Schroeder, A., Sheehy, A. M., Buettner, R., Proia, D. A., Kowolik, C. M., Xin, H., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.015 · Cited by 526 · see citing works
Self-citationZhang, S., Huang, W.-C., Li, P., Guo, H., Poh, S.-B., Brady, S. W., Xiong, Y., Tseng, L.-M., Li, S.-H., Ding, Z., et al. (2011) · Nature Medicine · doi:10.1038/nm.2309 · Cited by 515 · see citing works
Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer
Nefedova, Y., Huang, M., Kusmartsev, S., Bhattacharya, R., Cheng, P., Salup, R., Jove, R., & Gabrilovich, D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.464 · Cited by 464 · see citing works
Self-citationThe interplay between Src family kinases and receptor tyrosine kinases
Bromann, P. A., Körkaya, H., & Courtneidge, S. A. (2004) · Oncogene · doi:10.1038/sj.onc.1208079 · Cited by 451 · see citing works
Self-citationAoki, Y., Feldman, G. M., & Tosato, G. (2003) · Blood · doi:10.1182/blood-2002-07-2130 · Cited by 439 · see citing works
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
Niu, G., Bowman, T., Huang, M., Shivers, S., Reintgen, D., Daud, A., Chang, A., Kraker, A., Jove, R., & Yu, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205859 · Cited by 432 · see citing works
Self-citationTumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma
Ahir, B. K., Engelhard, H. H., & Lakka, S. S. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01892-8 · Cited by 435 · see citing works
Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer
Aggarwal, B. B., Sethi, G., Ahn, K. S., Sandur, S. K., Pandey, M. K., Kunnumakkara, A. B., Sung, B., & Ichikawa, H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1378.063 · Cited by 399 · see citing works
Activation of Stat3 in Human Melanoma Promotes Brain Metastasis
Xie, T.-X., Huang, F.-J., Aldape, K. D., Kang, S.-H., Liu, M., Gershenwald, J. E., Xie, K., Sawaya, R., & Huang, S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2674 · Cited by 393 · see citing works
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology
Pello, Ó. M., Pizzol, M. D., Mirolo, M., Soucek, L., Zammataro, L. A., Amabile, A., Doni, A., Nebuloni, M., Swigart, L. B., Evan, G. I., et al. (2011) · Blood · doi:10.1182/blood-2011-02-339911 · Cited by 387 · see citing works
Stat3 regulates genes common to both wound healing and cancer
Dauer, D. J., Ferraro, B., Song, L., Yu, B., Mora, L., Buettner, R., Enkemann, S., Jove, R., & Haura, E. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208469 · Cited by 381 · see citing works
Self-citationNewest findings on the oldest oncogene; how activated src does it
Frame, M. C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01111 · Cited by 369 · see citing works
STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3
Liu, L., McBride, K. M., & Reich, N. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501643102 · Cited by 348 · see citing works
Epithelial–mesenchymal transition: a new target in anticancer drug discovery
Marcucci, F., Stassi, G., & Maria, R. D. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.13 · Cited by 340 · see citing works
Vitamin D and calcium deficits predispose for multiple chronic diseases
Peterlik, M., & Cross, H. S. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01487.x · Cited by 339 · see citing works
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy
Tolomeo, M., & Cascio, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020603 · Cited by 323 · see citing works
Alternative Activation of STAT1 and STAT3 in Response to Interferon-γ
Qing, Y., & Stark, G. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406413200 · Cited by 317 · see citing works
Hui, L., Zatloukal, K., Scheuch, H., Stępniak-Konieczna, E., & Wagner, E. F. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37156 · Cited by 308 · see citing works
STAT3: A critical transcription activator in angiogenesis
Chen, Z., & Han, Z. (2007) · Medicinal Research Reviews · doi:10.1002/med.20101 · Cited by 302 · see citing works
Molecular biomarkers in acute myeloid leukemia
Prada‐Arismendy, J., Arroyave-Ospina, J. C., & Röthlisberger, S. (2016) · Blood Reviews · doi:10.1016/j.blre.2016.08.005 · Cited by 303 · see citing works
Kotha, A., Sekharam, M., Cilenti, L., Siddiquee, K., Khaled, A. R., Zervos, A. S., Carter, B., Turkson, J., & Jove, R. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0268 · Cited by 287 · see citing works
Self-citationTranscription Factor STAT3 as a Novel Molecular Target for Cancer Prevention
Xiong, A., Yang, Z., Shen, Y., Zhou, J., & Shen, Q. (2014) · Cancers · doi:10.3390/cancers6020926 · Cited by 283 · see citing works
Targeting STAT3 affects melanoma on multiple fronts
Kortylewski, M., Jove, R., & Yu, H. (2005) · Cancer and Metastasis Reviews · doi:10.1007/s10555-005-1580-1 · Cited by 282 · see citing works
Self-citationTurkson, J., Kim, J. S., Zhang, S., Yuan, J., Huang, M., Glenn, M. P., Haura, E. B., Sebti, S. M., Hamilton, A. D., & Jove, R. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.261.3.3 · Cited by 255 · see citing works
Self-citationLo, H., Cao, X., Zhu, H., & Ali‐Osman, F. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4923 · Cited by 253 · see citing works
Zhu, J., Blenis, J., & Yuan, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802785105 · Cited by 246 · see citing works
JAKs, STATs and Src kinases in hematopoiesis
Rane, S. G., & Reddy, E. P. (2002) · Oncogene · doi:10.1038/sj.onc.1205398 · Cited by 241 · see citing works
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
Büchert, M., Burns, C. J., & Ernst, M. (2015) · Oncogene · doi:10.1038/onc.2015.150 · Cited by 241 · see citing works
Monocytes Induce STAT3 Activation in Human Mesenchymal Stem Cells to Promote Osteoblast Formation
Nicolaidou, V., Wong, M. M., Redpath, A. N., Ersek, A., Baban, D. F., Williams, L. M., Cope, A. P., & Horwood, N. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039871 · Cited by 242 · see citing works
Han, W., & Lo, H. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.011 · Cited by 238 · see citing works
Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?
Jarnicki, A., Putoczki, T. L., & Ernst, M. (2010) · Cell Division · doi:10.1186/1747-1028-5-14 · Cited by 240 · see citing works
Lo, H., Hsu, S.-C., & Hung, M. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-9011-0 · Cited by 237 · see citing works
PDGF receptor signaling networks in normal and cancer cells
Demoulin, J., & Essaghir, A. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.03.003 · Cited by 238 · see citing works
Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell‐cycle control
Nagl, N. G., Wang, X., Patsialou, A., Scoy, M. V., & Morán, E. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601541 · Cited by 236 · see citing works
STAT3 as a therapeutic target in head and neck cancer
Leeman‐Neill, R. J., Lui, V. W. Y., & Grandis, J. R. (2006) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.6.3.231 · Cited by 224 · see citing works
Nori, S., Okada, Y., Nishimura, S., Sasaki, T., Itakura, G., Kobayashi, Y., Renault-Mihara, F., Shimizu, A., Koya, I., Yoshida, R., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.01.006 · Cited by 223 · see citing works
Series Introduction: JAK-STAT signaling in human disease
Schindler, C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15644 · Cited by 217 · see citing works
The c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211 · see citing works
Molecular Mechanisms of Resistance to Therapies Targeting the Epidermal Growth Factor Receptor
Camp, E. R., Summy, J. M., Bauer, T. W., Liu, W., Gallick, G. E., & Ellis, L. M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.397.11.1 · Cited by 210 · see citing works
MODULATION OF TRANSCRIPTION FACTORS BY CURCUMIN
Shishodia, S., Singh, T., & Chaturvedi, M. M. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-46401-5_4 · Cited by 210 · see citing works
Alvarez, J. V., Febbo, P. G., Ramaswamy, S., Loda, M. F., Richardson, A. L., & Frank, D. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4281 · Cited by 203 · see citing works
Ling, X., & Arlinghaus, R. B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2425 · Cited by 202 · see citing works
Essaghir, A., Toffalini, F., Knoops, L., Kallin, A., van Helden, J., & Demoulin, J. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq149 · Cited by 197 · see citing works
Calcium, vitamin D and cancer.
Peterlik, M., Grant, W. B., & Cross, H. S. (2009) · PubMed · Cited by 192 · see citing works
Targeting Cancer Stem Cells in Triple-Negative Breast Cancer
Park, S., Choi, J., & Nam, J. (2019) · Cancers · doi:10.3390/cancers11070965 · Cited by 190 · see citing works
Requirement of Histone Deacetylase Activity for Signaling by STAT1
Klampfer, L., Huang, J., Swaby, L.-A., & Augenlicht, L. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401359200 · Cited by 190 · see citing works
Turkson, J., Zhang, S., Palmer, J., Kay, H., Stanko, J., Mora, L. B., Sebti, S., Yu, H., & Jove, R. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1533.3.12 · Cited by 188 · see citing works
Self-citationSrc family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530
Chang, Y.-M., Bai, L., Liu, S., Yang, J. C., Kung, H.-J., & Evans, C. P. (2008) · Oncogene · doi:10.1038/onc.2008.250 · Cited by 185 · see citing works
Noman, M. Z., Buart, S., Van Pelt, J., Richon, C., Hasmim, M., Leleu, N., Suchorska, W. M., Jalil, A., Lecluse, Y., El Hage, F., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800854 · Cited by 183 · see citing works
Ogata, H., Kobayashi, T., Chinen, T., Takaki, H., Sanada, T., Minoda, Y., Koga, K., Takaesu, G., Maehara, Y., Iida, M., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.025 · Cited by 183 · see citing works
CTCF Haploinsufficiency Destabilizes DNA Methylation and Predisposes to Cancer
Kemp, C. J., Moore, J. M., Moser, R. D., Bernard, B. M., Teater, M. R., Smith, L. E., Rabaia, N. A., Gurley, K. E., Guinney, J., Busch, S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.004 · Cited by 182 · see citing works
Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck
Xi, S., Zhang, Q. H., Dyer, K. F., Lerner, E. C., Smithgall, T. E., Gooding, W. E., Kamens, J., & Grandis, J. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303499200 · Cited by 180 · see citing works
Zhang, W., Liu, Y., Yan, Z., Yang, H., Sun, W. Y., Yao, Y., Chen, Y., & Jiang, R. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000285 · Cited by 174 · see citing works
The Src-selective Kinase Inhibitor PP1 Also Inhibits Kit and Bcr-Abl Tyrosine Kinases
Tatton, L., Morley, G., Chopra, R., & Khwaja, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209321200 · Cited by 174 · see citing works
EGFR-Targeted Therapy in Malignant Glioma: Novel Aspects and Mechanisms of Drug Resistance
Lo, H. (2010) · Current Molecular Pharmacology · doi:10.2174/1874467211003010037 · Cited by 174 · see citing works
Klampfer, L. (2006) · Current Cancer Drug Targets · doi:10.2174/156800906776056491 · Cited by 171 · see citing works
Xi, S., Gooding, W. E., & Grandis, J. R. (2004) · Oncogene · doi:10.1038/sj.onc.1208316 · Cited by 170 · see citing works
Rac1 Function Is Required for Src-induced Transformation
Servitja, J., Marinissen, M. J., Sodhi, A., Bustelo, X. R., & Gutkind, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302960200 · Cited by 166 · see citing works
Dauchy, R. T., Xiang, S., Mao, L., Brimer, S., Wren, M. A., Yuan, L., Anbalagan, M., Hauch, A. T., Frasch, T., Rowan, B. G., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3156 · Cited by 161 · see citing works
Small-molecule inhibitors of the Myc oncoprotein
Fletcher, S., & Prochownik, E. V. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.03.005 · Cited by 153 · see citing works
Waris, G., Turkson, J., Hassanein, T., & Siddiqui, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.3.1569-1580.2005 · Cited by 153 · see citing works
RetractedTurkson, J., Zhang, S., Mora, L. B., Burns, A. C., Sebti, S. M., & Jove, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502694200 · Cited by 151 · see citing works
Self-citationInhibitor of MYC identified in a Kröhnke pyridine library
Hart, J. R., Garner, A. L., Yu, J., Ito, Y., Sun, M., Ueno, L. A., Rhee, J., Baksh, M. M., Stefan, E., Hartl, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319488111 · Cited by 150 · see citing works
Prochownik, E. V., & Vogt, P. K. (2010) · Genes & Cancer · doi:10.1177/1947601910377494 · Cited by 150 · see citing works
A human multi-lineage hepatic organoid model for liver fibrosis
Guan, Y., Enejder, A., Wang, M., Fang, Z., Cui, L., Chen, S.-Y., Wang, J., Tan, Y., Wu, M., Chen, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26410-9 · Cited by 149 · see citing works
Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation
Braydich‐Stolle, L. K., Kostereva, N. V., Dym, M., & Hofmann, M.-C. C. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.013 · Cited by 149 · see citing works
Selective Inhibition of c-Myc/Max Dimerization and DNA Binding by Small Molecules
Kiessling, A., Sperl, B., Hollis, A., Eick, D., & Berg, T. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.05.011 · Cited by 148 · see citing works
miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT
Kao, C.-J., Martiniez, A., Shi, X.-B., Yang, J. C., Evans, C. P., Dobi, A., White, R. D., & Kung, H.-J. (2013) · Oncogene · doi:10.1038/onc.2013.200 · Cited by 147 · see citing works
Annexin A2 Is a Novel RNA-binding Protein
Filipenko, N. R., MacLeod, T. J., Yoon, C.-S., & Waisman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311951200 · Cited by 145 · see citing works
Miguel, M. P. D., Cheng, L., Holland, E. C., Federspiel, M. J., & Donovan, P. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122249399 · Cited by 145 · see citing works
Amaya, M. L., Sheth, A. I., Pei, S., Jones, C. L., Krug, A., Ye, H., Minhajuddin, M., Winters, A. C., Furtek, S. L., Gamboni, F., et al. (2021) · Blood · doi:10.1182/blood.2021013201 · Cited by 143 · see citing works
Good Gone Bad: One Toxin Away From Disease for Bacteroides fragilis
Valguarnera, E., & Wardenburg, J. B. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.003 · Cited by 140 · see citing works
MicroRNA-205 Inhibits Src-Mediated Oncogenic Pathways in Renal Cancer
Majid, S., Saini, S., Dar, A. A., Hirata, H., Shahryari, V., Tanaka, Y., Yamamura, S., Ueno, K., Zaman, M. S., Singh, K., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3666 · Cited by 135 · see citing works
Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab
Dunn, E. F., Iida, M., Myers, R. A., Campbell, D. A., Hintz, K. A., Armstrong, E. A., Li, C., & Wheeler, D. L. (2011) · Oncogene · doi:10.1038/onc.2010.430 · Cited by 133 · see citing works
“These membrane-associated non-RTKs are transducers of mitogenic signaling emanating from a number of RTKs, including EGFR, HER2, fibroblast growth factor receptor, platelet-derived growth factor, colonystimulating factor-1 receptor and hepatocyte growth receptor (Muthuswamy et al., 1994; Belsches et al., 1997; Mao et…”
BackgroundAmin, H. M., Medeiros, L. J., Ma, Y., Feretzaki, M., Das, P., Leventaki, V., Rassidakis, G. Z., O’Connor, S. L., McDonnell, T. J., & Lai, R. L. (2003) · Oncogene · doi:10.1038/sj.onc.1206849 · Cited by 131 · see citing works
Critical Role of STAT3 in IL-6–Mediated Drug Resistance in Human Neuroblastoma
Ara, T., Nakata, R., Sheard, M. A., Shimada, H., Buettner, R., Groshen, S. G., Ji, L., Yu, H., Jove, R., Seeger, R. C., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2353 · Cited by 130 · see citing works
Self-citationZhang, F., Li, C., Halfter, H., & Liu, J. (2003) · Oncogene · doi:10.1038/sj.onc.1206158 · Cited by 129 · see citing works
Zhou, J., Ong, C. N., Hur, G. M., & Shen, H. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.12.014 · Cited by 128 · see citing works
- Authors
- Bowman, T., Broome, M. A., Sinibaldi, D., Wharton, W., Pledger, W. J., Sedivy, J. M., Irby, R., Yeatman, T., Courtneidge, S. A., & Jove, R.
- Affiliations
- University of South Florida (US)
- Pfizer (United States) (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-06-12
- Volume
- 98
- Issue
- 13
- Pages
- 7319-7324
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC34666
- OpenAlex
- W2042794591
- Cited by
- 488
- References
- 54
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 8 · 2023: 24 · 2022: 12 · 2021: 13 · 2020: 12 · 2019: 13 · 2018: 13 · 2017: 20 · 2016: 15 · 2015: 24 · 2014: 21 · 2013: 20 · 2012: 30
- FWCI
- 11.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Moffitt Cancer Center
- National Cancer Institute (R01CA055652, CA-55652, CA 67360, R01CA067360)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- STAT3, c-Myc, v-Src, Src family kinases, platelet-derived growth factor, cell transformation, SU6656, STAT signaling, NIH3T3 cells, oncogenic transformation
- MeSH terms
- Animals, Cell Division, Cell Line, Transformed, Cell Transformation, Neoplastic, DNA-Binding Proteins, Gene Expression Regulation, Models, Biological, Platelet-Derived Growth Factor, Recombinant Proteins, Signal Transduction, Trans-Activators, Genes, myc, Proto-Oncogene Proteins c-myc, Genes, src, 3T3 Cells, STAT3 Transcription Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
