The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Requirement of the Yeast RTH1 5′ to 3′ Exonuclease for the Stability of Simple Repetitive DNA
Abstract
Simple repetitive DNA sequences are unstable in human colorectal cancers and a variety of other cancers. Mutations in the DNA mismatch repair genes MSH2 , MLH1 , and PMS1 result in elevated rates of spontaneous mutation and cause a marked increase in the instability of simple repeats. Compared with the wild type, a null mutation in the yeast RTH1 gene, which encodes a 5′ to 3′ exonuclease, was shown to increase the rate of instability of simple repetitive DNA by as much as 280 times and to increase the spontaneous mutation rate by 30 times. Epistasis analyses were consistent with the hypothesis that this RTH1 -encoded nuclease has a role in the MSH2-MLH-1-PMS1 mismatch repair pathway.
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Citations
Cites
The distribution of the numbers of mutants in bacterial populations
Lea, D. E., & Coulson, C. A. (1949) · Journal of Genetics · doi:10.1007/bf02986080 · Cited by 1,450
Cited by
DNA Mismatch Repair: Functions and Mechanisms
Iyer, R. R., Pluciennik, A., Burdett, V., & Modrich, P. L. (2006) · Chemical Reviews · doi:10.1021/cr0404794 · Cited by 905
Eukaryotic DNA mismatch repair
Kolodner, R. D., & Marsischky, G. T. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80013-6 · Cited by 870
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
Harfe, B. D., & Jinks-Robertson, S. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.359 · Cited by 608
Biochemistry and genetics of eukaryotic mismatch repair.
Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.12.1433 · Cited by 592
Lieber, M. R. (1997) · BioEssays · doi:10.1002/bies.950190309 · Cited by 446
Metadata
- Authors
- Johnson, R. E., Kovvali, G. K., Prakash, L., & Prakash, S.
- Venue
- Science
- Published
- 1995-07-14
- Volume
- 269
- Issue
- 5221
- Pages
- 238-240
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981277651
- Cited by
- 196
- References
- 1
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Johnson, R. E., Kovvali, G. K., Prakash, L., & Prakash, S. (1995). Requirement of the Yeast RTH1 5′ to 3′ Exonuclease for the Stability of Simple Repetitive DNA. Science. https://doi.org/10.1126/science.7618086
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
