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Ultrasound-Mediated Transdermal Protein Delivery
Abstract
Transdermal drug delivery offers a potential method of drug administration. However, its application has been limited to a few low molecular weight compounds because of the extremely low permeability of human skin. Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible. It was possible to deliver and control therapeutic doses of proteins such as insulin, interferon γ, and erythropoeitin across human skin. Low-frequency ultrasound is thus a potential noninvasive substitute for traditional methods of drug delivery, such as injections.
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Citations
Cited by
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832
Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
Mitragotri, S., Burke, P. A., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4363 · Cited by 1,702
Self-citationAdvances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Self-citationReprogrammable recovery and actuation behaviour of shape-memory polymers
Lendlein, A., & Gould, O. E. C. (2019) · Nature Reviews Materials · doi:10.1038/s41578-018-0078-8 · Cited by 723
Therapeutic applications of ultrasound
ter Haar, G. (2007) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.07.005 · Cited by 721
Metadata
- Authors
- Mitragotri, S., Blankschtein, D., & Langer, R.
- Venue
- Science
- Published
- 1995-08-11
- Volume
- 269
- Issue
- 5225
- Pages
- 850-853
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016299303
- Cited by
- 791
- References
- 0
- FWCI
- 18.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mitragotri, S., Blankschtein, D., & Langer, R. (1995). Ultrasound-Mediated Transdermal Protein Delivery. Science. https://doi.org/10.1126/science.7638603
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