The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
Abstract
A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8 + T cells; CD4 + T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo.
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Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
CTLA-4 is a second receptor for the B cell activation antigen B7.
Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.3.561 · Cited by 1,685
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Leach, D. R., Krummel, M. F., & Allison, J. P. (1996) · Science · doi:10.1126/science.271.5256.1734 · Cited by 3,955
Self-citationCD28/B7 SYSTEM OF T CELL COSTIMULATION
Lenschow, D. J., Walunas, T. L., & Bluestone, J. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.233 · Cited by 2,717
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Metadata
- Authors
- Townsend, S. E., & Allison, J. P.
- Venue
- Science
- Published
- 1993-01-15
- Volume
- 259
- Issue
- 5093
- Pages
- 368-370
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092312916
- Cited by
- 1,136
- References
- 2
- FWCI
- 44.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Townsend, S. E., & Allison, J. P. (1993). Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells. Science. https://doi.org/10.1126/science.7678351
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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